Evidence map›Paper›PMID 33723998›Full record

ArticleACS infectious diseases2021

Acridones Are Highly Potent Inhibitors of

P Holland Alday, Erin V McConnell, Jan M Boitz Zarella, Rozalia A Dodean, Papireddy Kancharla, Jane X Kelly, J Stone Doggett

Abstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Evaluating acridones as novel therapeutics for human babesiosis.Antimicrobial agents and chemotherapy · 2026
    Article
  2. Targeting Mitochondrial Function inInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. In vitro anti-parasitic effect of the alkaloids harmaline and piperine on Toxoplasma gondii.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2024
    Article
  6. Inhibition ofJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  7. Structure-activity relationships ofExpert opinion on drug discovery · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

P Holland AldayPortland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0002-0142-2438
Erin V McConnellPortland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Jan M Boitz ZarellaPortland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Rozalia A DodeanPortland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0001-5002-4607
Papireddy KancharlaDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0002-6381-1236
Jane X KellyPortland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0001-8871-0207
J Stone DoggettPortland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0002-6098-1520

Funding

Novel Broad-spectrum AntimalarialsR01AI093784 · NIAID · PORTLAND STATE UNIVERSITY · PI KELLY, JANE X, KREISHMAN-DEITRICK, MARA · 2012 to 2016
$3.5M
Novel Therapeutic Strategies for ELQ-422, a preclinical Toxoplasmosis Drug CandidateI01BX004522 · VA · PORTLAND VA MEDICAL CENTER · PI Joseph Stone Doggett · 2019 to 2026
–
Development of the potent anti-malarial and anti-Toxoplasma drug, ELQ-316IK2BX002440 · VA · PORTLAND VA MEDICAL CENTER · PI DOGGETT, JOSEPH STONE · 2014 to 2018
–
BLRD VA I01 BX004522BLRD VA IK2 BX002440NIAID NIH HHS R01 AI093784
6 · The paper itself

Abstract

Acridone derivatives, which have been shown to have

Indexed as

ParasitesToxoplasmaToxoplasmosisAcridonesAnimalsMiceAcridonesacridonecytochrome bc1dihydroorotate dehydrogenasedrug discoverytoxoplasma

Identifiers

PMID33723998
PMCPMC8273083

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.