Evidence map›Paper›PMID 33723888›Full record

ArticleAngewandte Chemie (International ed. in English)2021

A Colorimetric Method for Quantifying Cis and Trans Alkenes Using an Indicator Displacement Assay.

Stephanie A Valenzuela, Hannah S N Crory, Chao-Yi Yao, James R Howard, Gabriel Saucedo, A Prasanna de Silva, Eric V Anslyn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Stephanie A ValenzuelaDepartment of Chemistry, University of Texas at Austin, 100 E 24th Street, Norman Hackerman Building Room 114A, Austin, TX, 78712, USA.ORCID 0000-0002-0399-275X
Hannah S N CrorySchool of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, UK.ORCID 0000-0001-9803-6762
Chao-Yi YaoSchool of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, UK.ORCID 0000-0003-4250-5034
James R HowardDepartment of Chemistry, University of Texas at Austin, 100 E 24th Street, Norman Hackerman Building Room 114A, Austin, TX, 78712, USA.ORCID 0000-0002-9184-6954
Gabriel SaucedoDepartment of Chemistry, University of Texas at Austin, 100 E 24th Street, Norman Hackerman Building Room 114A, Austin, TX, 78712, USA.
A Prasanna de SilvaSchool of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, UK.
Eric V AnslynDepartment of Chemistry, University of Texas at Austin, 100 E 24th Street, Norman Hackerman Building Room 114A, Austin, TX, 78712, USA.ORCID 0000-0002-5137-8797
Queen's University Belfast · GBThe University of Texas at Austin · US

Funding

Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
NIH HHS S10 OD021508
6 · The paper itself

Abstract

A colorimetric indicator displacement assay (IDA) amenable to high-throughput experimentation was developed to determine the percentage of cis and trans alkenes. Using 96-well plates two steps are performed: a reaction plate for dihydroxylation of the alkenes followed by an IDA screening plate consisting of an indicator and a boronic acid. The dihydroxylation generates either erythro or threo vicinal diols from cis or trans alkenes, depending upon their syn- or anti-addition mechanisms. Threo diols preferentially associate with the boronic acid due to the creation of more stable boronate esters, thus displacing the indicator to a greater extent. The generality of the protocol was demonstrated using seven sets of cis and trans alkenes. Blind mixtures of cis and trans alkenes were made, resulting in an average error of ±2 % in the percentage of cis or trans alkenes, and implementing E

Indexed as

ColorimetryAlkenesMolecular StructureStereoisomerismAlkenesalkene stereochemistrycolorimetric assaysdihydroxylationhigh-throughput screeninghost-guest systems

Identifiers

PMID33723888
PMCPMC8184614
OpenAlexW3137111954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.