Evidence map›Paper›PMID 33723886›Full record

ArticleJournal of veterinary internal medicine2021

Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism.

Thirawut Kongtasai, Evelyne Meyer, Dominique Paepe, Sofie Marynissen, Pascale Smets, Femke Mortier, Kristel Demeyere, Eva Vandermeulen, Emmelie Stock, Eva Buresova and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Renal Biomarkers in Companion Animals-A Review.Animals : an open access journal from MDPI · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Thirawut KongtasaiSmall Animal Department, Ghent University, Merelbeke, Belgium.ORCID https://orcid.org/0000-0002-3458-4978
Evelyne MeyerDepartment of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Dominique PaepeSmall Animal Department, Ghent University, Merelbeke, Belgium.
Sofie MarynissenSmall Animal Department, Ghent University, Merelbeke, Belgium.
Pascale SmetsSmall Animal Department, Ghent University, Merelbeke, Belgium.
Femke MortierSmall Animal Department, Ghent University, Merelbeke, Belgium.
Kristel DemeyereDepartment of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Eva VandermeulenDepartment of Medical Imaging of Domestic Animals, Ghent University, Merelbeke, Belgium.
Emmelie StockDepartment of Medical Imaging of Domestic Animals, Ghent University, Merelbeke, Belgium.ORCID https://orcid.org/0000-0002-9982-1532
Eva BuresovaDavies Veterinary Specialists, Higham Gobion, United Kingdom.ORCID https://orcid.org/0000-0002-8805-8455
Pieter DefauwLumbry Park Veterinary Specialists, Alton, United Kingdom.ORCID https://orcid.org/0000-0002-5098-8411
Luc DuchateauBiometrics Research Group, Ghent University, Merelbeke, Belgium.
Sylvie DaminetSmall Animal Department, Ghent University, Merelbeke, Belgium.
Ghent University · BECarolina Veterinary Specialists · USWillows Veterinary Centre and Referral Service · GB

Funding

IDEXX LaboratoriesMahidol University
6 · The paper itself

Abstract

backgroundLiver-type fatty acid-binding protein (L-FABP) and neutrophil gelatinase-associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats.

objectiveTo evaluate urinary and serum L-FABP and NGAL concentrations in CKD cats and in hyperthyroid cats before and after radioiodine ( ANIMALS: Nine CKD cats, 45 healthy cats and hyperthyroid cats at 3 time points including before (T0, n = 49), 1 month (T1, n = 49), and 11 to 29 months after (T2, n = 26)

methodsCross-sectional and longitudinal study. Serum L-FABP (sL-FABP), serum NGAL (sNGAL), urinary L-FABP (uL-FABP), and urinary NGAL (uNGAL) were compared between the 3 groups and between hyperthyroid cats before and after treatment. Data are reported as median (min-max).

resultsCKD cats had significantly higher sL-FABP (13.50 [3.40-75.60] ng/ml) and uL-FABP/Cr (4.90 [0.97-2139.44] µg/g) than healthy cats (4.25 [1.34-23.25] ng/ml; P = .01 and 0.46 [0.18-9.13] µg/g; P < .001, respectively). Hyperthyroid cats at T0 had significantly higher uL-FABP/Cr (0.94 [0.15-896.00] µg/g) than healthy cats (P < .001), thereafter uL-FABP/Cr significantly decreased at T2 (0.54 [0.10-76.41] µg/g, P = .002). For the detection of CKD, uL-FABP/Cr had 100% (95% confidence interval [CI], 66.4-100.0) sensitivity and 93.2% (95% CI, 81.3-98.6) specificity. There were no significant differences in sNGAL and uNGAL/Cr between the 3 groups. CONCLUSIONS AND CLINICAL IMPORTANCE: L-FABP, but not NGAL, is a potential biomarker for the detection of early CKD in cats. Utility of uL-FABP to predict azotemia after treatment in hyperthyroid cats remains unknown.

Indexed as

Acute Kidney InjuryCat DiseasesHyperthyroidismRenal Insufficiency, ChronicAcute-Phase ProteinsAnimalsBiomarkersCatsCross-Sectional StudiesFatty Acid-Binding ProteinsIodine RadioisotopesLipocalin-2LipocalinsLiverLongitudinal StudiesProto-Oncogene ProteinsAcute-Phase ProteinsBiomarkersFatty Acid-Binding ProteinsIodine RadioisotopesLipocalin-2LipocalinsProto-Oncogene ProteinsbiomarkerscatsCKDhyperthyroidL-FABPNGAL

Identifiers

PMID33723886
PMCPMC8162613
OpenAlexW3138441870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.