Evidence map›Paper›PMID 33723811›Full record

ArticleBrain imaging and behavior2021

Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia.

Wenwen Gao, Guangfei Li, Xiaowei Han, Zeyu Song, Shuai Zhao, Feiyi Sun, Hong Ma, Ailing Cui, Yige Wang, Xiuxiu Liu and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Wenwen Gao *Department of Radiology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.
Guangfei Li *School of Life Science, Beijing Institute of Technology, No.5 Zhongguancun South Street, Haidian District, Beijing, 100081, China.
Xiaowei HanDepartment of Radiology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.
Zeyu SongSchool of Life Science, Beijing Institute of Technology, No.5 Zhongguancun South Street, Haidian District, Beijing, 100081, China.
Shuai ZhaoChangzhi Medical College, Shanxi, 046000, China.
Feiyi SunSchool of Life Science, Beijing Institute of Technology, No.5 Zhongguancun South Street, Haidian District, Beijing, 100081, China.
Hong MaSchool of Life Science, Beijing Institute of Technology, No.5 Zhongguancun South Street, Haidian District, Beijing, 100081, China.
Ailing CuiAnatomy Department of Changzhi Medical College, Shanxi, 046000, China.
Yige WangDepartment of Radiology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.
Xiuxiu LiuDepartment of Radiology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.
Yue ChenDepartment of Radiology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.
Lu ZhangDepartment of Science and Education, Shangluo Central Hospital, Shangluo, 726000, China.
Guolin MaDepartment of Radiology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China. maguolin1007@qq.com.ORCID http://orcid.org/0000-0002-4044-025X
Xiaoying TangSchool of Life Science, Beijing Institute of Technology, No.5 Zhongguancun South Street, Haidian District, Beijing, 100081, China. xiaoying@bit.edu.cn.
Beijing Institute of Technology · CNChina-Japan Friendship Hospital · CNChangzhi Medical College · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNShangluo Central Hospital · CN

Funding

National Natural Science Foundation of China 81571641National Natural Science Foundation of China 81971585The National Key Research and Development Program of China 2016YFC1307001
6 · The paper itself

Abstract

Schizophrenia is a severe psychiatric disease while its etiology and effective treatment are not completely clear. A rat model of schizophrenia was previously established by transfecting EGR3 gene into the hippocampus of rats. This study aimed to investigate the behavioral and cerebral alterations of the schizophrenic model rats and the risperidone effects. Twenty-six rats were divided into 3 groups: schizophrenia model group (E group), risperidone treatment group (T group), and healthy control group (H group). Morris water maze and open field test were used as behavioral tests, resting-state functional magnetic resonance imaging (fMRI) was performed after EGR3 gene transfection and risperidone therapy. Graph analyses were used for examining cerebral alterations of the rats. Behavioral tests demonstrated reduced spatial working memory and exploring unfamiliar space ability in schizophrenic model rats. Graph analyses revealed reduced regional architectures in the olfactory bulb, nucleus accumbens, and pineal gland in group E compared to group H (p < 0.05), while group T showed increased regional architecture in pineal gland compared to group E (p < 0.05). Besides, the regional architectures in the olfactory bulb, nucleus accumbens were lower in group T than group H, while the hippocampus showed increased regional architecture in group T compared to group H (p < 0.05). Schizophrenia induced several regional alterations in the cerebrum while risperidone can reverse part of these alterations. This study lends support for future research on the pathology of schizophrenia and provides new insights on the role of risperidone in schizophrenia.

Indexed as

Antipsychotic AgentsSchizophreniaAnimalsBrainEarly Growth Response Protein 3Magnetic Resonance ImagingMemory, Short-TermRatsRisperidoneTransfectionAntipsychotic AgentsEarly Growth Response Protein 3Egr3 protein, ratRisperidoneBehavioral testGraph analysisResting‐state fMRIRisperidoneSchizophrenia

Identifiers

PMID33723811
OpenAlexW3138519698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.