Evidence map›Paper›PMID 33723754›Full record

ArticleTranslational stroke research2022

Prediction of Outcome After Endovascular Embolectomy in Anterior Circulation Stroke Using Biomarkers.

Fani Pujol-Calderón, Henrik Zetterberg, Erik Portelius, Pia Löwhagen Hendén, Alexandros Rentzos, Jan-Erik Karlsson, Kina Höglund, Kaj Blennow, Lars E Rosengren

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Neuron-Specific Enolase-What Are We Measuring?International journal of molecular sciences · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fani Pujol-CalderónDepartment of Psychiatry & Neurochemistry, University of Gothenburg, Gothenburg, Sweden. fani.pujol.calderon@gu.se.ORCID 0000-0001-7920-2884
Henrik ZetterbergDepartment of Psychiatry & Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Erik PorteliusDepartment of Psychiatry & Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Pia Löwhagen HendénDepartment of Anesthesiology and Intensive Care Medicine, University of Gothenburg, Gothenburg, Sweden.
Alexandros RentzosDepartment of Radiology, University of Gothenburg, Gothenburg, Sweden.
Jan-Erik KarlssonDepartment of Neurology, University of Gothenburg, Gothenburg, Sweden.
Kina HöglundDepartment of Psychiatry & Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Kaj BlennowDepartment of Psychiatry & Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Lars E RosengrenDepartment of Neurology, University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SESahlgrenska University Hospital · SE

Funding

European Research Council 681712
6 · The paper itself

Abstract

Stroke is a major public health problem that can cause a long-term disability or death due to brain damage. Serious stroke is frequently caused by a large vessel occlusion in the anterior circulation, which should be treated by endovascular embolectomy if possible. In this study, we investigated the use of the brain damage biomarkers tau, NFL, NSE, GFAp, and S100B to understand the progression of nervous tissue damage and their relationship to outcome in such stroke after endovascular treatment. Blood samples were taken from 90 patients pre-treatment and 2 h, 24 h, 48 h, 72 h and 3 months after endovascular treatment. Stroke-related neurological deficit was estimated using the National Institute of Health Stroke Scale (NIHSS) at admission and at 24 h. Neurological outcome was evaluated at 3 months. After stroke, tau, NFL, GFAp and S100B increased in a time dependent manner, while NSE remained constant over time. At 3 months, tau and GFAp levels were back to normal whereas NFL was still high. Tau, NFL and GFAp correlated well to outcome, as well as to infarct volume and NIHSS at 24 h. The best time for prediction of poor outcome was different for each biomarker. However, the combination of NIHSS at 24 h with either tau, NFL or GFAp at 48 h gave the best prediction. The use of biomarkers in the early setting after endovascular treatment of stroke will lead to a simplified and standardized way to estimate the nervous tissue damage and possibly complement the clinical judgement in foreseeing the need of rehabilitation measures.

Indexed as

Brain InjuriesEndovascular ProceduresStrokeBiomarkersEmbolectomyHumansTreatment OutcomeBiomarkersBiomarkerEndovascular treatmentPrediction of outcomeStroke

Identifiers

PMID33723754
PMCPMC8766380
OpenAlexW3138297425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.