ReviewPain and therapy2021
Pain in Women: A Perspective Review on a Relevant Clinical Issue that Deserves Prioritization.
Review in Pain and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- The analgesic effect of localized vibration: a systematic review. Part 1: the neurophysiological basis.European journal of physical and rehabilitation medicine · 2022Pooled it
- Exploring pain sensitivity changes after acceptance and attention bias modification trainings: preliminary evidence on fear of pain and attention bias.Scientific reports · 2026Trial
- Comparative analysis of early and late recurrence rates in perianal fistula surgery.Experimental and therapeutic medicine · 2026Article
- Activation of the G-protein coupled estrogen receptor 1 (GPER1) reduces transient receptor potential vanilloid 1 (TRPV1) activity and human iPSC-derived nociceptive neuron firing.Stem cell research & therapy · 2026Article
- The impact of sex and gender on Fibromyalgia Syndrome: data from the Italian Fibromyalgia Registry.Internal and emergency medicine · 2026Article
- Analgesic and antioxidant potential of tulathromycin: evidence from molecular docking, in vitro assay, and in vivo model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Invisible pain: Sex/gender differences in pain-related stigma.Acta psychologica · 2026Article
- Identifying Sex Differences in Adverse Events Reported on Opioid Drugs in the FDA's Adverse Event Reporting System (FAERS).Pharmaceuticals (Basel, Switzerland) · 2026Article
- Fibromyalgia, Eating Disorders and Rehabilitation: The Nrf2 Link.Antioxidants (Basel, Switzerland) · 2026Review
- Sex differences in pain in 2 large and diverse US databases.Pain reports · 2026Article
- Orofacial Pain at a Tertiary Clinic: Comorbidities and Psychological Conditions Using the International Classification of Orofacial Pain (ICOP) Criteria.Journal of pain research · 2026Article
- Musculoskeletal pain in university students: lifestyle determinants of prevalence and burden.Frontiers in public health · 2026Article
- Article
- Climate Change and Air Pollution-Related Health Effects on Pain.International journal of environmental research and public health · 2025Review
- Sex- and APOE Genotype-Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2.Aging cell · 2025Article
- Chronic intermittent ethanol produces nociception through endocannabinoid-independent mechanisms in mice.Neuropharmacology · 2025Article
- Choosing well: A narrative review on chronic pain and decision-making.The journal of pain · 2025Review
- Systemic Inflammation at the Crossroad of Major Depressive Disorder and Comorbidities: A Narrative Review.International journal of molecular sciences · 2025Review
- The association between loneliness and pain, and the role of physical health and distress: an analysis in 139 countries.Scientific reports · 2025Article
- Interactive interdisciplinary pain research in adolescent and young adult females: a pilot investigation of brain, physiological, and emotional functioning following orthopedic surgery.Journal of pediatric psychology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGender equity and gender medicine are opportunities not to be missed, and this Expert Group Opinion Paper on pain in women aims to review the treatment of pain conditions mainly affecting women, as well as the fundamental aspects of the different clinical response to drug treatment between the genders, and what can be done for gender-specific rehabilitation.
methodsPerspective review.
resultsGenotypic and phenotypic differences in pain between the sexes are conditioned by anatomical, physiological, neural, hormonal, psychological, social, and cultural factors, such as the response to pharmacological treatment to control pain. The examination of these factors shows that women are affected by pain diseases more frequently and severely than men and that they report pain more frequently and with a lower pain threshold than men. Some forms of pain are inherently related to gender differences, such as pain related to the genitourinary system. However, other forms of chronic pain are seen more frequently in women than men, such as migraine, rheumatological, and musculoskeletal pain, in particular fibromyalgia. DISCUSSION: Research is needed into the pathophysiological basis for gender differences in the generation of acute pain and maintenance of chronic pain, including the factors that put women at higher risk for developing chronic pain. In addition, different specialties need to collaborate to develop gender-related diagnostic and therapeutic guidelines, and healthcare professionals need to upskill themselves in the appropriate management of pain using existing diagnostic tools and therapeutic options.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.