Evidence map›Paper›PMID 33723704›Full record

ArticleAnnals of biomedical engineering2021

A Simplified In Silico Model of Left Ventricular Outflow in Patients After Transcatheter Mitral Valve Replacement with Anterior Leaflet Laceration.

Keshav Kohli, Zhenglun Alan Wei, Vahid Sadri, Tiffany Netto, John C Lisko, Adam B Greenbaum, Vasilis Babaliaros, John N Oshinski, Ajit P Yoganathan

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Effect of catheter ablation on the hemodynamics of the left atrium : Hemodynamics of ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Keshav Kohli *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.ORCID https://orcid.org/0000-0002-1469-4088
Zhenglun Alan Wei *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Vahid SadriWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Tiffany NettoWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
John C LiskoEmory University Structural Heart and Valve Center, Atlanta, USA.
Adam B GreenbaumEmory University Structural Heart and Valve Center, Atlanta, USA.
Vasilis BabaliarosEmory University Structural Heart and Valve Center, Atlanta, USA.
John N OshinskiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Ajit P YoganathanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA. ajit.yoganathan@bme.gatech.edu.ORCID http://orcid.org/0000-0001-5818-1316
Georgia Institute of Technology · USValve (United States) · US

Funding

American Heart Association 20PRE35200392
6 · The paper itself

Abstract

In silico modeling has been proposed as a tool to simulate left ventricular (LV) outflow tract (LVOT) obstruction in patients undergoing transcatheter mitral valve replacement (TMVR). This study validated a simplified approach to simulate LV outflow hemodynamics in the setting of TMVR with anterior leaflet laceration, a clinical technique used to mitigate the risk of LVOT obstruction. Personalized, 3-dimensional computational fluid dynamics models were developed from computed tomography images of six patients who underwent TMVR with anterior leaflet laceration. LV outflow hemodynamics were simulated using the patient-specific anatomy and the peak systolic flow rate as boundary conditions. The peak outflow velocity, a clinically relevant hemodynamic metric, was extracted from each simulation (v

Indexed as

Heart Valve Prosthesis ImplantationModels, CardiovascularPatient-Specific ModelingAgedAged, 80 and overCoronary CirculationFemaleHeart Valve ProsthesisHeart VentriclesHemodynamicsHumansHydrodynamicsLacerationsMiddle AgedMitral ValveReproducibility of ResultsComputational fluid dynamicsLAMPOONLVOT obstructionNeo-LVOTPatient-specific modelingTranscatheter mitral valve replacement

Identifiers

PMID33723704
OpenAlexW3136217554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.