SynthesisDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2021
Management of chyle leaks following esophageal resection: a systematic review.
Synthesis in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Indocyanine green-assisted lymphography for intraoperative chyle leak prevention during esophageal cancer surgery: a systematic review of the literature.Frontiers in oncology · 2026Pooled it
- Traumatic chylothorax management post-coronary artery bypass grafting - A systematic review.Asian cardiovascular & thoracic annals · 2025Pooled it
- Outcomes of Chylothorax Nonoperative Management After Cardiothoracic Surgery: A Systematic Review and Meta-Analysis.Brazilian journal of cardiovascular surgery · 2023Pooled it
- Fluorescence Lymphography Using Indocyanine Green During Esophagectomy for Cancer to Prevent Chyle Leakage: A Propensity Score Matched Analysis.Annals of surgical oncology · 2026Observational
- Clinical outcomes of non-traumatic chylothorax at a Singapore tertiary referral hospital.BMJ open respiratory research · 2026Article
- Thoracic duct outflow obstruction increases thoracic duct pressure above central venous pressure supporting thoracic duct decompression.JVS-vascular science · 2026Article
- Lymphoma Induced Chylothorax Complicated by Disseminated Histoplasmosis and Esophagopericardial Fistula.Clinical case reports · 2025Article
- Intervention lymphatic leakage after esophageal surgery due to esophageal cancer: A case report.Radiology case reports · 2024Article
- Chylothorax: pathophysiology, diagnosis, and management-a comprehensive review.Journal of thoracic disease · 2024Review
- Post-traumatic pleural effusion: Don't forget the chylothorax!Respirology case reports · 2024Article
- Minimally Invasive Treatment of Chyle Leak After Thyroidectomy and Cervical Lymph Node Dissection in Patients with Thyroid Carcinoma: Results of a Study Involving 36 Patients.Therapeutics and clinical risk management · 2024Article
- Intractable chylous leak after radical esophagectomy treated with radiotherapy.Journal of cardiothoracic surgery · 2023Article
- Article
- Clinical characteristics of chylothorax: results from the International Collaborative Effusion database.ERJ open research · 2023Article
- Hybrid Minimally Invasive Esophagectomy for Carcinoma Oesophagus: Experience at Tertiary Care Centre in North Karnataka.Indian journal of surgical oncology · 2023Article
- The essential role of thoracic duct embolization in management of traumatic iatrogenic chylothorax.Jornal vascular brasileiro · 2023Article
- Transhiatal bilateral thoracic duct ligation for duplicated thoracic duct injury after esophagectomy: a case report.Surgical case reports · 2022Article
- Adequate Management of Postoperative Complications after Esophagectomy: A Cornerstone for a Positive Outcome.Cancers · 2022Review
- Chylothorax After Schwannoma Resection.Cureus · 2022Article
- Risk Factors, Diagnosis and Management of Chyle Leak Following Esophagectomy for Cancers: An International Consensus Statement.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChyle leakage is an uncommon but potentially life-threatening complication following esophageal resections. The optimal management strategy is not clear, with a limited evidence base.
methodsSearches were conducted up to 31 December 2020 on MEDLINE, Embase, and Web of Science for randomized trials or retrospective studies that evaluated the management of chyle leakage following esophageal resection. Two authors independently screened studies, extracted data, and assessed for bias. The protocol was prospectively registered on PROSPERO (CRD: 42021224895) and reported in accordance with preferred reporting items for systematic reviews and meta-analyses guidelines.
resultsA total of 530 citations were reviewed. Twenty-five studies, totaling 1016 patients met the inclusion criteria, including two low-quality clinical trials and 23 retrospective case series. Heterogeneity of study design and outcomes prevented meta-analysis. The overall incidence of chyle leak/fistula was 3.2%. Eighteen studies describe management of chyle leaks conservatively, 17 by surgical ligation of the thoracic duct, 5 by pleurodesis, and 6 described percutaneous lymphangiography with thoracic duct embolization or disruption.
conclusionsThe evidence base for optimal management of chyle leakage postesophagectomy is lacking, which may be related to its low incidence. There is a paucity of high-quality prospective studies directly comparing treatment modalities, but there is some low-certainty evidence that percutaneous approaches have reduced morbidity but lower efficacy compared with surgery. Further high-quality, prospective studies that compare interventions at different levels of severity are needed to determine the optimal approach to treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.