Evidence map›Paper›PMID 33723523›Full record

ArticleAdvances in radiation oncology

The Case for Brachytherapy: Why It Deserves a Renaissance.

Vonetta M Williams, Jenna M Kahn, Nikhil G Thaker, Sushil Beriwal, Paul L Nguyen, Douglas Arthur, Daniel Petereit, Brandon A Dyer

Abstract read
In one paragraph

Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A review of artificial intelligence in brachytherapy.Journal of applied clinical medical physics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vonetta M WilliamsDepartment of Radiation Oncology, University of Washington, Seattle, Washington.
Jenna M KahnDepartment of Radiation Oncology, Oregon Health & Science University, Portland, Oregon.
Nikhil G ThakerDepartment of Radiation Oncology, Arizona Oncology, Tucson, Arizona.
Sushil BeriwalDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Paul L NguyenDepartment of Radiation Oncology, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.
Douglas ArthurDepartment of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia.
Daniel PetereitDepartment of Radiation Oncology, Monument Health Cancer Care Institute, Rapid City, South Dakota.
Brandon A DyerDepartment of Radiation Oncology, University of Washington, Seattle, Washington.

Funding

Advancing Palliative Care in Northern Plains American IndiansR01CA240080 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ARMSTRONG, KATRINA, PETEREIT, DANIEL G · 2019 to 2023
$3.9M
NCI NIH HHS R01 CA240080
6 · The paper itself

Abstract

The recent global events related to the coronavirus disease of 2019 pandemic have significantly changed the medical landscape and led to a shift in oncologic treatment perspectives. There is a renewed focus on preserving treatment outcomes while maintaining medical accessibility and decreasing medical resource utilization. Brachytherapy, which is a vital part of the treatment course of many cancers (particularly prostate and gynecologic cancers), has the ability to deliver hypofractionated radiation and thus shorten treatment time. Studies in the early 2000s demonstrated a decline in brachytherapy usage despite data showing equivalent or even superior treatment outcomes for brachytherapy in disease sites, such as the prostate and cervix. However, newer data suggest that this trend may be reversing. The renewed call for shorter radiation courses based on data showing equivalent outcomes will likely establish hypofractionated radiation as the standard of care across multiple disease sites. With shifting reimbursement, brachytherapy represents the pinnacle in hypofractionated, conformal radiation therapy, and with extensive long-term data in support of the treatment modality brachytherapy is primed for a renaissance.

Identifiers

PMID33723523
PMCPMC7940781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.