ArticleNature neuroscience2021
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 90 citations in OpenAlex.
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Bidirectional Hopf bifurcation control of narrowband gamma oscillations in Parkinson's disease by the corticothalamic system via non-canonical pathways.Journal of computational neuroscience · 2026Article
- Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice.Molecular psychiatry · 2026Article
- The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits.bioRxiv : the preprint server for biology · 2026Article
- The Parafascicular Role in Updating Action from a Spatial to a Visual Strategy Is Driven by Its Glutamatergic Mesencephalic Locomotor Region Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Risk of Parkinsonism After Exposure to Different Types of Gadolinium-Based Contrast Agents: A Nationwide Population-Based Cohort Study of 222,977 Individuals.Korean journal of radiology · 2026Article
- Article
- Cellular and synaptic properties of molecularly defined neurons in the external globus pallidus.iScience · 2025Article
- Unraveling Pallido-Retrorubral Circuits Linking the Basal Ganglia to Limbic Areas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer's disease and dementia with lewy bodies.Alzheimer's research & therapy · 2025Article
- Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa.CNS neuroscience & therapeutics · 2025Article
- Deep brain stimulation alleviates Parkinsonian motor deficits through desynchronizing GABA release in mice.Nature communications · 2025Article
- Article
- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- GPe Projections to the Retrorubral Field Give Rise to Diverging GABAergic and DAergic Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits.Current biology : CB · 2024Article
- Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The basal ganglia regulate a wide range of behaviors, including motor control and cognitive functions, and are profoundly affected in Parkinson's disease (PD). However, the functional organization of different basal ganglia nuclei has not been fully elucidated at the circuit level. In this study, we investigated the functional roles of distinct parvalbumin-expressing neuronal populations in the external globus pallidus (GPe-PV) and their contributions to different PD-related behaviors. We demonstrate that substantia nigra pars reticulata (SNr)-projecting GPe-PV neurons and parafascicular thalamus (PF)-projecting GPe-PV neurons are associated with locomotion and reversal learning, respectively. In a mouse model of PD, we found that selective manipulation of the SNr-projecting GPe-PV neurons alleviated locomotor deficit, whereas manipulation of the PF-projecting GPe-PV neurons rescued the impaired reversal learning. Our findings establish the behavioral importance of two distinct GPe-PV neuronal populations and, thereby, provide a new framework for understanding the circuit basis of different behavioral deficits in the Parkinsonian state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.