Evidence map›Paper›PMID 33723432›Full record

ArticleNature chemical biology2021

Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.

Christopher F Bennett, Katherine E O'Malley, Elizabeth A Perry, Eduardo Balsa, Pedro Latorre-Muro, Christopher L Riley, Chi Luo, Mark Jedrychowski, Steven P Gygi, Pere Puigserver

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Review
  5. Article
  6. Article
  7. Recurrent Breast Cancer Cells Depend onbioRxiv : the preprint server for biology · 2025
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  13. Formation of ICell metabolism · 2025
    Article
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  16. Article
  17. Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Christopher F BennettDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1927-0732
Katherine E O'MalleyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Elizabeth A PerryDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Eduardo BalsaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Pedro Latorre-MuroDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6794-3535
Christopher L RileyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Chi LuoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Mark JedrychowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Pere PuigserverDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. pere_puigserver@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-0884-2718
Harvard University · USDana-Farber Cancer Institute · US

Funding

New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin BiologyR01GM067945 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2003 to 2024
$10.5M
Transcriptional Control of Mitochondrial Bioenergetic FunctionR01DK081418 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2008 to 2021
$5.2M
Insulin Signaling and Metabolic Effects through CLK2 KinaseR01DK089883 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2011 to 2020
$3.8M
Metabolic and Bioenergetic Control in Mitochondrial DiseasesR01GM121452 · NIGMS · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2017 to 2020
$1.5M
Chemical Approaches to Rescue Human Mitochondrial Disease MutationsF30DE028206 · NIDCR · HARVARD MEDICAL SCHOOL · PI PERRY, ELIZABETH AGUILAR · 2018 to 2022
$190k
Characterization of genetic modifiers of bioenergetic rescue in mitochondrial disease cell linesF32GM125243 · NIGMS · DANA-FARBER CANCER INST · PI BENNETT, CHRISTOPHER F. · 2017 to 2020
$188k
NIDCR NIH HHS F30 DE028206NIDDK NIH HHS R01 DK081418NIDDK NIH HHS R01 DK089883NIGMS NIH HHS F32 GM125243NIGMS NIH HHS R01 GM067945NIGMS NIH HHS R01 GM121452
6 · The paper itself

Abstract

The protein complexes of the mitochondrial electron transport chain exist in isolation and in higher order assemblies termed supercomplexes (SCs) or respirasomes (SC I+III

Indexed as

Electron TransportDihydroorotate DehydrogenaseElectron Transport Complex IIIElectron Transport Complex IVHigh-Throughput Nucleotide SequencingHumansLipidsMetabolomicsMitochondriaMolecular StructureNucleotidesOxidoreductases Acting on CH-CH Group DonorsOxygen ConsumptionPeroxisomesPhospholipid EthersPhospholipidsDihydroorotate DehydrogenaseElectron Transport Complex IIIElectron Transport Complex IVLipidsNucleotidesOxidoreductases Acting on CH-CH Group DonorsPhospholipid EthersPhospholipidsUridine

Identifiers

PMID33723432
PMCPMC8159895
OpenAlexW3136056317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.