ArticleNature biomedical engineering2021
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients.
Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 136 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
Multispectral Optoacoustic Tomography (MSOT) and Ultrasound Localization Microscopy (ULM) as Diagnostic Imaging for Lymphatic, Venous and Arteriovenous Malformations
Who cites it
136 citing papers in PubMed, 353 citations in OpenAlex.
- Trial
- In Vivo Wide-Field Mapping of Microvascular Dynamics in Orthotopic GL261 Gliomas by Super-Resolution Ultrasound Imaging.Annals of biomedical engineering · 2026Article
- Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.EBioMedicine · 2026Article
- Fast 3-D Ultrasound Localization Microscopy via Projection-Based Processing Framework.IEEE transactions on medical imaging · 2026Article
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Voice-controlled super-resolution ultrasound imaging and reporting powered by multimodal large language models.NPJ digital medicine · 2026Article
- Clinically translatable ultrasound localization microscopy reveals cerebrovascular remodelling and prognosis in patients with traumatic brain injury.Nature biomedical engineering · 2026Article
- Modal Superposition-Induced Novel Directional Responses in a Low-Damping Biomimetic Microphone for Sound Source Localization.Sensors (Basel, Switzerland) · 2026Article
- Microbubble Backscattering Intensity Improves the Sensitivity of Three-Dimensional (3-D) Functional Ultrasound Localization Microscopy (fULM).IEEE transactions on medical imaging · 2026Article
- Localization-based techniques for super-resolution imaging of vascular dynamics.Innovation (Cambridge (Mass.)) · 2026Review
- Dual-frequency fiber-array photoacoustic computed tomography for high-resolution deep brain imaging.Light, science & applications · 2026Article
- Fusing photoacoustic microscopy and ultrasound imaging: an artificial intelligence strategy for vessel enhancement in interventional guidance.Biomedical optics express · 2026Article
- Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy.Nature biomedical engineering · 2026Article
- Active-targeted nano-hemostatic for hemostasis and brain microenvironment optimization in intracerebral hemorrhage therapy.Materials today. Bio · 2026Article
- Computational design of foldable origami-based compressive ultrasound sensing.Scientific reports · 2026Article
- Photo-activated ultrasound localization imaging with laser-activated nanodroplets.Communications engineering · 2026Article
- Rotational ultrasound and photoacoustic tomography of the human body.Nature biomedical engineering · 2026Article
- A reproducible ultrasound localization microscopy framework for the quantitative imaging of hepatocellular carcinoma on a clinical ultrasound system.Theranostics · 2026Article
- Optoacoustic-Guided Magnetic Microrobot Platform for Precision Drug Delivery.Advanced materials (Deerfield Beach, Fla.) · 2026Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Changes in cerebral blood flow are associated with stroke, aneurysms, vascular cognitive impairment, neurodegenerative diseases and other pathologies. Brain angiograms, typically performed via computed tomography or magnetic resonance imaging, are limited to millimetre-scale resolution and are insensitive to blood-flow dynamics. Here we show that ultrafast ultrasound localization microscopy of intravenously injected microbubbles enables transcranial imaging of deep vasculature in the adult human brain at microscopic resolution and the quantification of haemodynamic parameters. Adaptive speckle tracking to correct for micrometric brain-motion artefacts and ultrasonic-wave aberrations induced during transcranial propagation allowed us to map the vascular network of tangled arteries to functionally characterize blood-flow dynamics at a resolution of up to 25 μm and to detect blood vortices in a small deep-seated aneurysm in a patient. Ultrafast ultrasound localization microscopy may facilitate the understanding of brain haemodynamics and of how vascular abnormalities in the brain are related to neurological pathologies.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.