ArticleBritish journal of cancer2021
The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank.
Article in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Adiposity associations with risk of colorectal cancer: a systematic review.Obesity (Silver Spring, Md.) · 2025Pooled it
- Mechanisms underlying obesity-malignancy connection: a systematic narrative review.Journal of physiology and biochemistry · 2025Pooled it
- Normal weight obesity, circulating biomarkers and risk of breast cancer: a prospective cohort study and meta-analysis.British journal of cancer · 2025Pooled it
- The relationship between central obesity and risk of breast cancer: a dose-response meta-analysis of 7,989,315 women.Frontiers in nutrition · 2023Pooled it
- BMI and Breast Subcutaneous Fat: Potential Indicators for Ultrasound Diagnosis of Breast Cancer?Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- DXA-Derived Visceral and Subcutaneous Adipose Tissue and Postmenopausal Breast Cancer Mortality.Current oncology (Toronto, Ont.) · 2026Article
- Metabolic Syndrome Components and Cancer Risk in Normal-Weight Subjects: Systematic Review and Meta-Analysis in over 18 Million Individuals.Journal of clinical medicine · 2026Review
- The Role of "Metabolic Instability" as a New Risk Criterion in the Pathogenesis of Endometrial Cancer.Cancers · 2025Review
- Central obesity may account for most of the colorectal cancer risk linked to obesity: evidence from the UK Biobank prospective cohort.International journal of obesity (2005) · 2025Article
- The association between the healthy lifestyle index and MRI-derived body composition measurements in the UK Biobank study.Scientific reports · 2025Article
- Unveiling the causal link between metabolic factors and ovarian cancer risk using Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- Predicted lean body mass trajectories, and cancer risk and cancer-specific and all-cause mortality: A prospective cohort study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Update on Adipose Tissue and Cancer.Endocrine reviews · 2023Article
- Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat.Cancers · 2022Article
- Obesity and Breast Cancer Risk: The Oncogenic Implications of Metabolic Dysregulation.The Journal of clinical endocrinology and metabolism · 2022Article
- Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.Obesity (Silver Spring, Md.) · 2022Review
- Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women.NPJ breast cancer · 2022Article
- Cancer Risk in Normal Weight Individuals with Metabolic Obesity: A Narrative Review.Cancer prevention research (Philadelphia, Pa.) · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe association between body fat composition and risk of cancer in normal weight individuals (body mass index (BMI) 18.5-24.9 kg/m
methodsWe examined the association of measures of adiposity with risk of incident cancers of the breast (postmenopausal), endometrium, ovary and colon/rectum among 149,928 normal weight individuals (40-70 years) who were enrolled in the UK Biobank cohort between 2006 and 2010.
resultsAll of the body fat measures were positively associated with invasive postmenopausal breast cancer risk (hazard ratios (HR) for the uppermost quintile (Q5) versus the lowest quintile (Q1) ranged from 1.32 (95% CI: 1.09-1.60) for waist circumference (WC) to 1.56 (1.28-1.90) for BMI). Trunk fat mass index (HR
conclusionThe findings of this study suggest that the current normal weight category based on BMI includes individuals who are at increased risk of some obesity-related cancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.