ArticleScientific reports2021
Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Gadolinium Orthovanadate Nanoparticles Normalizes Glycemia, Insulin Resistance, and Glucose Tolerance in Rats with Experimental Type 2 Diabetes Mellitus.Biological trace element research · 2026Article
- Vitamin D3 Enhances Endothelial Function and Improves Vascular Reactivity in an Experimental Model of Type 2 Diabetes Mellitus in Rats.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The roles of melatonin and potassium channels in relaxation response to ang 1-7 in diabetic rat isolated aorta.Cytotechnology · 2025Article
- Evaluating the impact of type 2 diabetes mellitus on pulmonary vascular function and the development of pulmonary fibrosis.Frontiers in endocrinology · 2024Review
- Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats.Cardiovascular therapeutics · 2024Article
- Vascular nitric oxide resistance in type 2 diabetes.Cell death & disease · 2023Review
- Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy.Frontiers in endocrinology · 2023Review
- Effect of Carotid Body Denervation on Systemic Endothelial Function in a Diabetic Animal Model.Advances in experimental medicine and biology · 2023Article
- Therapeutic Benefits of Pomegranate Flower Extract: A Novel Effect That Reduces Oxidative Stress and Significantly Improves Diastolic Relaxation in Hyperglycemic In Vitro in Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulation and the mechanisms promoting the dysfunction, using pulmonary artery (PA) and aorta. A high-fat (HF, 3 weeks 60% lipid-rich diet) and a high-fat/high-sucrose (HFHSu, combined 60% lipid-rich diet and 35% sucrose during 25 weeks) groups were used as prediabetes and T2D rat models. We found that T2D progression differently affects endothelial function and vascular contractility in the aorta and PA, with the contractile machinery being altered in the PA and aorta in prediabetes and T2D animals; and endothelial function being affected in both models in the aorta but only affected in the PA of T2D animals, meaning that PA is more resistant than aorta to endothelial dysfunction. Additionally, PA and systemic endothelial dysfunction in diabetic rats were associated with alterations in the nitrergic system and inflammatory pathways. PA dysfunction in T2D involves endothelial wall mineralization. The understanding of the mechanisms behind PA dysfunction in T2D can lead to significant advances in both preventative and therapeutic treatments of pulmonary disease-associated diabetes.
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