Evidence map›Paper›PMID 33723360›Full record

ArticleScientific reports2021

The influence of sex and body mass index on the association between soluble neprilysin and risk of heart failure hospitalizations.

Julio Núñez, Eduardo Núñez, Elena Revuelta-López, Gema Miñana, Jaume Barallat, Vicent Bodi, Juan Sanchis, Alberto Aimo, Michele Emdin, Josep Lupón and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Julio NúñezCardiology Department, Hospital Clínico Universitario, INCLIVA, Departamento de Medicina, Universitat de València, Avda. Blasco Ibáñez 17, 46010, Valencia, Spain. yulnunez@gmail.com.ORCID 0000-0003-1672-7119
Eduardo NúñezCardiology Department, Hospital Clínico Universitario, INCLIVA, Departamento de Medicina, Universitat de València, Avda. Blasco Ibáñez 17, 46010, Valencia, Spain.
Elena Revuelta-LópezCIBER Cardiovascular, Madrid, Spain.
Gema MiñanaCardiology Department, Hospital Clínico Universitario, INCLIVA, Departamento de Medicina, Universitat de València, Avda. Blasco Ibáñez 17, 46010, Valencia, Spain.
Jaume BarallatBiochemistry Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Vicent BodiCardiology Department, Hospital Clínico Universitario, INCLIVA, Departamento de Medicina, Universitat de València, Avda. Blasco Ibáñez 17, 46010, Valencia, Spain.
Juan SanchisCardiology Department, Hospital Clínico Universitario, INCLIVA, Departamento de Medicina, Universitat de València, Avda. Blasco Ibáñez 17, 46010, Valencia, Spain.
Alberto AimoInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Michele EmdinCardiology Division, University Hospital of Pisa, Pisa, Italy.
Josep LupónCIBER Cardiovascular, Madrid, Spain.
Oliver HusserKlinik für Innere Medizin I, Kardiologie, St. Johannes-Hospital Dortmund, Dortmund, Germany.
Antoni Bayes-GenisCIBER Cardiovascular, Madrid, Spain.
Universitat de València · ESScuola Superiore Sant'Anna · ITUniversitat Autònoma de Barcelona · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESHospital Universitari Germans Trias i Pujol · ESSt.-Johannes-Hospital Dortmund · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A higher neprilysin activity has been suggested in women. In this retrospective analysis, we evaluated the association of sex and body mass index (BMI) with soluble neprilysin (sNEP) and recurrent admissions among 1021 consecutive HF outpatients. The primary and secondary endpoints were the number of HF hospitalizations and all-cause mortality, respectively. The association between sNEP with either endpoint was evaluated across sex and BMI categories (≥ 25 kg/m

Indexed as

BiomarkersBody Mass IndexAdultAftercareAgedAge FactorsDisease SusceptibilityFemaleHeart FailureHeart Function TestsHospitalizationHumansMaleMiddle AgedNeprilysinRetrospective StudiesBiomarkersNeprilysin

Identifiers

PMID33723360
PMCPMC7960699
OpenAlexW3136437510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.