ArticleNature communications2021
Effect of X-ray free-electron laser-induced shockwaves on haemoglobin microcrystals delivered in a liquid jet.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Statistical crystallography reveals an allosteric network in SARS-CoV-2 MCommunications biology · 2026Article
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- Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs.Nature methods · 2024Article
- Time-resolved crystallography of boric acid binding to the active site serine of the β-lactamase CTX-M-14 and subsequent 1,2-diol esterification.Communications chemistry · 2024Article
- Appraising protein conformational changes by resampling time-resolved serial x-ray crystallography data.Structural dynamics (Melville, N.Y.) · 2024Article
- A comparative review of time-resolved x-ray and electron scattering to probe structural dynamics.Structural dynamics (Melville, N.Y.) · 2024Review
- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- Kilohertz droplet-on-demand serial femtosecond crystallography at the European XFEL station FXE.Structural dynamics (Melville, N.Y.) · 2024Article
- Article
- X-ray free-electron laser induced acoustic microscopy (XFELAM).Photoacoustics · 2024Article
- Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook.Structure (London, England : 1993) · 2023Review
- A phenomenological model of the X-ray pulse statistics of a high-repetition-rate X-ray free-electron laser.IUCrJ · 2023Article
- Emerging Time-Resolved X-Ray Diffraction Approaches for Protein Dynamics.Annual review of biophysics · 2023Review
- Growing and making nano- and microcrystals.Nature protocols · 2023Review
- A multi-million image Serial Femtosecond Crystallography dataset collected at the European XFEL.Scientific data · 2022Article
- 3D printed devices and infrastructure for liquid sample delivery at the European XFEL.Journal of synchrotron radiation · 2022Article
- Microfluidic liquid sheets as large-area targets for high repetition XFELs.Frontiers in molecular biosciences · 2022Article
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- Article
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Authors and funding
29 authors.
Funding
Abstract
X-ray free-electron lasers (XFELs) enable obtaining novel insights in structural biology. The recently available MHz repetition rate XFELs allow full data sets to be collected in shorter time and can also decrease sample consumption. However, the microsecond spacing of MHz XFEL pulses raises new challenges, including possible sample damage induced by shock waves that are launched by preceding pulses in the sample-carrying jet. We explored this matter with an X-ray-pump/X-ray-probe experiment employing haemoglobin microcrystals transported via a liquid jet into the XFEL beam. Diffraction data were collected using a shock-wave-free single-pulse scheme as well as the dual-pulse pump-probe scheme. The latter, relative to the former, reveals significant degradation of crystal hit rate, diffraction resolution and data quality. Crystal structures extracted from the two data sets also differ. Since our pump-probe attributes were chosen to emulate EuXFEL operation at its 4.5 MHz maximum pulse rate, this prompts concern about such data collection.
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