ArticleNature communications2021
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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69citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Metabolomic biomarkers and metabolic remodelling in genetically characterised hypertrophic cardiomyopathy: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Retatrutide and lipid and metabolite profiles in participants with obesity with or without type 2 diabetes.The Journal of clinical endocrinology and metabolism · 2026Trial
- Amino Acid Metabolism in Health and Disease.MedComm · 2026Review
- Biocompatible SABRE Hyperpolarization of [1-Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Dynamic [Research square · 2026Article
- ACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation.Nature communications · 2026Article
- Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review).International journal of molecular medicine · 2026Review
- Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.bioRxiv : the preprint server for biology · 2026Article
- GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis.Circulation · 2026Article
- Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis.Nature communications · 2026Article
- Microbial Metabolite 4EPS Inhibits AT1R to Reduce Blood Pressure and Aortic Aneurysm Outcome.Hypertension (Dallas, Tex. : 1979) · 2026Article
- BCAA Metabolic Dyshomeostasis in Cardiovascular Disease: Pathogenic Mechanisms and Intervention.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Review
- Metabolomic Markers of Left Ventricular Structure, Diastolic Function, and Risk of Coronary Heart Disease: A Longitudinal Study in American Indian Individuals.Journal of the American Heart Association · 2026Article
- Circulating Branched-Chain Amino Acids are Associated with Higher Odds of Obesity: Findings from the FiLWHEL Study.Nutrition and metabolic insights · 2026Article
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Role of branched chain amino acid metabolism on aging.Biogerontology · 2025Review
- Epigenetic regulation of intracellular branched-chain amino acid homeostasis maintains a normal lifespan.iScience · 2025Article
- Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.Molecular metabolism · 2025Article
- Quantitation of BCAA and BCKA in plasma and patient-centric dried blood microsamples in a clinical setting.Bioanalysis · 2025Article
- Effects of different ratio of sweet sorghum silage to corn silage diets on serum metabolome of lactating dairy cows.Tropical animal health and production · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 2 institutions in 1 country.
Jacquelyn M Walejko *Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Bridgette A Christopher *Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Scott B Crown *Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-1983-2101
Guo-Fang ZhangDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Adrian Pickar-OliverDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Takeshi YoneshiroUCSF Diabetes Center, San Francisco, CA, USA.
Matthew W FosterDuke Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-0212-2346
Stephani PageDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Stephan van VlietDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-8992-555X
Olga IlkayevaDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-9779-0883
Michael J MuehlbauerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Matthew W CarsonEli Lilly and Company, Indianapolis, IN, US.
Joseph T BrozinickEli Lilly and Company, Indianapolis, IN, US.
Craig D HammondEli Lilly and Company, Indianapolis, IN, US.
Ruth E GimenoEli Lilly and Company, Indianapolis, IN, US.
M Arthur MoseleyDuke Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, USA.
Shingo KajimuraUCSF Diabetes Center, San Francisco, CA, USA.ORCID 0000-0003-0672-5910
Charles A GersbachDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0003-1478-4013
Christopher B NewgardDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-1293-691X
Phillip J WhiteDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. phillip.white@duke.edu.ORCID 0000-0002-0957-425X
Robert W McGarrahDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. robert.mcgarrah@duke.edu.ORCID 0000-0001-6693-7152
Duke University · USEli Lilly (United States) · US
Funding
ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MNational Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MPilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI P Darrell Neufer · 2020 to 2026
$11.0MMULTIDISCIPLINARY HEART &VASCULAR DISEASEST32HL007101 · NHLBI · DUKE UNIVERSITY · PI FREEDMAN, NEIL J. · 1985 to 2020
$9.8MMolecular mechanisms of UCP1-independent pathways in metabolic healthR01DK097441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shingo Kajimura · 2012 to 2026
$5.9MMitochondrial Metabolite Compartmentalization in Health and DiseaseDP1DK126160 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2020 to 2025
$4.4MMitochondrial BCAA transporter in physiology and diseaseR01DK125283 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2021 to 2025
$1.8MCRISPR/Cas9-Based Gene Editing for the Correction of Duchenne Muscular DystrophyR01AR069085 · NIAMS · DUKE UNIVERSITY · PI GERSBACH, CHARLES A. · 2016 to 2020
$1.7MThe Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Mycocardial Fuel SectionK08HL135275 · NHLBI · DUKE UNIVERSITY · PI MCGARRAH, ROBERT WALKER · 2018 to 2022
$713k13C-Metabolic Flux Analysis for Understanding Cardiac Energy HomeostasisF32HL137398 · NHLBI · DUKE UNIVERSITY · PI CROWN, SCOTT B. · 2017 to 2019
$155kNCRR NIH HHS M01 RR001271NHLBI NIH HHS F32 HL137398NHLBI NIH HHS K08 HL135275NHLBI NIH HHS L30 HL124508NHLBI NIH HHS T32 HL007101NIAMS NIH HHS R01 AR069085NIDDK NIH HHS DP1 DK126160NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS P30 DK124723NIDDK NIH HHS R01 DK097441NIDDK NIH HHS R01 DK125283NIDDK NIH HHS U2C DK119886
Abstract
Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-
Indexed as
Amino Acids, Branched-ChainAnimalsHeartHemiterpenesKeto AcidsMaleMiceMice, Inbred C57BLMitochondriaObesityRatsValinealpha-ketoisovalerateAmino Acids, Branched-ChainHemiterpenesKeto AcidsValine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.