ArticleTranslational psychiatry2021
Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response.The FEBS journal · 2025Article
- Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations.Nature neuroscience · 2025Article
- The CB1 receptor: linking impulsivity and substance use disorder.Frontiers in neuroscience · 2025Review
- Psychotomimetic compensation versus sensitization.Pharmacology research & perspectives · 2024Review
- Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling.Cells · 2024Review
- Morphometric Analyses of Macrophages.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Feasibility of applying a noninvasive method for sleep monitoring based on mouse behaviors.Brain and behavior · 2023Article
- Demographic and Selection Histories of Populations Across the Sahel/Savannah Belt.Molecular biology and evolution · 2022Article
- The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.Scientific reports · 2022Article
- Stress vulnerability shapes disruption of motor cortical neuroplasticity.Translational psychiatry · 2022Article
- Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.Frontiers in psychiatry · 2022Review
- Enhancing Endocannabinoid Control of Stress with Cannabidiol.Journal of clinical medicine · 2021Review
- Quality of Life and a Surveillant Endocannabinoid System.Frontiers in neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Psychosocial stress is one of the main environmental factors contributing to the development of psychiatric disorders. In humans and rodents, chronic stress is associated with elevated inflammatory responses, indicated by increased numbers of circulating myeloid cells and activation of microglia, the brain-resident immune cells. The endocannabinoid system (ECS) regulates neuronal and endocrine stress responses via the cannabinoid receptor 1 (CB1). CB1-deficient mice (Cnr1
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.