ArticleAsian journal of andrology
Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Anti-Müllerian hormone predicts positive sperm retrieval in men with idiopathic non-obstructive azoospermia-findings from a multi-centric cross-sectional study.Human reproduction (Oxford, England) · 2023Pooled it
- Preoperative Varicocele Severity and Sperm Concentration Are Associated with Absence of Internal Spermatic Vein Reflux in Patients Undergoing Varicocele Embolization: Results from A Cross-Sectional Study.The world journal of men's health · 2026Article
- Age Disparity in Couples Seeking First Medical Help for Infertility Has Changed Over the Last Twenty Years: A Socio-Demographic Analysis.The world journal of men's health · 2026Article
- Establishing reference values and evaluating diagnostic utility of scrotal ultrasound for azoospermia subtypes: A cross-sectional study in Guangdong, China.The ultrasound journal · 2026Article
- NOA masquerading as OA: Rethinking the role of testis biopsy from an East Asian perspective.Journal of the Chinese Medical Association : JCMA · 2026Article
- Article
- Predictive value of testicular elastography on the outcome of percutaneous testicular sperm aspiration in patients with azoospermia.Scientific reports · 2026Article
- Normal Reference Values for Testicular Volume in Adult Somali Men: A Retrospective Study.Research and reports in urology · 2026Article
- Epidemiological characteristics and temporal trends of male infertility in Egypt (2012-2022): Analysis of 3,037 consecutive cases.Arab journal of urology · 2026Article
- Global Andrology Forum (GAF) Clinical Guidelines on the Management of Non-obstructive Azoospermia: Bridging the Gap between Controversy and Consensus.The world journal of men's health · 2026Article
- Short-Term Hormonal Changes Following Microdissection Testicular Sperm Extraction among Men with Non-Obstructive Azoospermia: Findings from a Large Longitudinal Prospective Multicentric Study.The world journal of men's health · 2025Article
- Oxidative Stress and Semen Quality Among Night- and Day-Shift Workers: A Cross-Sectional Study.Antioxidants (Basel, Switzerland) · 2025Article
- Contemporary Diagnostic Work-Up for Male Infertility: Emphasizing Comprehensive Baseline Assessment.The world journal of men's health · 2025Review
- The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study.The world journal of men's health · 2025Article
- Idiopathic male infertility - what are we missing?Arab journal of urology · 2025Article
- Low Birth Weight is Associated with Sperm DNA Fragmentation and Assisted Reproductive Technology Outcomes in Primary Infertile Men: Results of a Cross-Sectional Study.The world journal of men's health · 2024Article
- Prevalence and clinical implications of biochemical hypogonadism in patients with nonobstructive azoospermia undergoing infertility evaluation.F&S reports · 2024Article
- Ultrasonographic evaluation of the rete testis thickness: a promising approach to differentiate obstructive from nonobstructive azoospermia.Asian journal of andrology · 2023Article
- Is There a Relevant Clinical Impact in Differentiating IdiopathicThe world journal of men's health · 2023Article
- Article
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testicular volume (TV) is considered a good clinical marker of hormonal and spermatogenic function. Accurate reference values for TV measures in infertile and fertile men are lacking. We aimed to assess references values for TV in white-European infertile men and fertile controls. We analyzed clinical and laboratory data from 1940 (95.0%) infertile men and 102 (5.0%) fertile controls. Groups were matched by age using propensity score weighting. TV was assessed using a Prader orchidometer (PO). Circulating hormones and semen parameters were investigated in every male. Descriptive statistics, Spearman's correlation, and logistic regression models tested potential associations between PO-estimated TV values and clinical variables. Receiver operating characteristic (ROC) curves were used to find TV value cutoffs for oligoasthenoteratozoospermia (OAT) and nonobstructive azoospermia (NOA) status in infertile men. The median testicular volume was smaller in infertile than that of fertile men (15.0 ml vs 22.5 ml; P < 0.001). TV positively correlated with total testosterone, sperm concentration, and progressive sperm motility (all P ≤ 0.001) in infertile men. At multivariable logistic regression analysis, infertile status (P < 0.001) and the presence of left varicocele (P < 0.001) were associated with TV < 15 ml. Testicular volume thresholds of 15 ml and 12 ml had a good predictive ability for detecting OAT and NOA status, respectively. In conclusion, infertile men have smaller testicular volume than fertile controls. TV positively correlated with total testosterone, sperm concentration, and progressive motility in infertile men, which was not the case in the age-matched fertile counterparts.
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