Evidence map›Paper›PMID 33723076›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm.

Jinshu Xu, Jun Li, Ting Zhang, Huihui Jiang, Aarthi Ramakrishnan, Bernd Fritzsch, Li Shen, Pin-Xian Xu

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 55 citations in OpenAlex.

  1. A regulatory axis for tonotopic MYO7A expression in cochlear hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Sponge bHLH Gene Expression inInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Fgf8Neuroscience bulletin · 2023
    Article
  15. Article
  16. Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023
    Review
  17. Review
  18. Review
  19. Review
  20. Three distinctProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jinshu XuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-6287-5633
Jun LiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-8220-6365
Ting ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Huihui JiangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Aarthi RamakrishnanDepartment of Neurosciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Bernd FritzschDepartment of Biology, University of Iowa, Iowa City, IA 52242-1324.ORCID 0000-0002-4882-8398
Li ShenDepartment of Neurosciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Pin-Xian XuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029; pinxian.xu@mssm.edu.ORCID 0000-0002-8957-6780
Icahn School of Medicine at Mount Sinai · USUniversity of Iowa · US

Funding

Transcriptional networks establishing the precise gene expression states that define neurosensory cell identity in the inner earR01DC014718 · NIDCD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PIN-XIAN XU · 2016 to 2026
$5.2M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC014718
6 · The paper itself

Abstract

Specification of Sox2

Indexed as

Chromatin Assembly and DisassemblyCell DifferentiationCell LineageChromatinComputational BiologyEctodermGene Expression ProfilingGene Expression Regulation, DevelopmentalHomeodomain ProteinsNeuronsSOXB1 Transcription FactorsChromatinHomeodomain ProteinsSOXB1 Transcription Factorschromatin remodelersotic neurosensory lineageregulation of otic Sox2 expressionSox2 enhancerstranscription factors

Identifiers

PMID33723076
PMCPMC8000026
OpenAlexW3136670775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.