ArticleProceedings of the National Academy of Sciences of the United States of America2021
Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cortical Gradients Support Mental Time Travel into the Past and Future: Evidence from Activation Likelihood Estimation Meta-analysis.Neuropsychology review · 2026Pooled it
- The method of loci in the context of psychological research: A systematic review and meta-analysis.British journal of psychology (London, England : 1953) · 2025Pooled it
- Impaired autobiographical remembering and future thinking in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2026Article
- Latent persistence in fMRI dynamics during human memory consolidation.Neuroimage. Reports · 2026Article
- Association Between Anterior Hippocampal Gyrification and Episodic Memory Performance in Neurotypical Young Adults.Hippocampus · 2026Article
- Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making.bioRxiv : the preprint server for biology · 2026Article
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- Concept Cells and the Neural Bases of Human Memory.Acta physiologica (Oxford, England) · 2026Review
- Echoes of time: Organization of episodic autobiographical memories in the brain according to their remoteness.NeuroImage · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Salient Memory: Effects of Distributed Learning on Cortical Regions During Memory Retrieval.Human brain mapping · 2025Article
- Specialization of the human hippocampal long axis revisited.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterizing BOLD activation patterns in the human hippocampus with laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The hippocampus dissociates present from past and future goals.Nature communications · 2024Article
- FMRI correlates of autobiographical memory: Comparing silent retrieval with narrated retrieval.Neuropsychologia · 2024Article
- Decoding the dynamic perception of risk and speed using naturalistic stimuli: A multivariate, whole-brain analysis.Human brain mapping · 2024Article
- Human brain activity and functional connectivity associated with verbal long-term memory consolidation across 1 month.Frontiers in human neuroscience · 2024Article
- Harnessing slow event-related fMRI to investigate trial-level brain-behavior relationships during object identification.Frontiers in human neuroscience · 2024Article
- Multidimensional assessment of time perception along the continuum of Alzheimer's Disease and evidence of alterations in subjective cognitive decline.Scientific reports · 2023Article
- Functional network reconfiguration supporting memory-guided attention.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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7 authors.
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Abstract
The necessity of the human hippocampus for remote autobiographical recall remains fiercely debated. The standard model of consolidation predicts a time-limited role for the hippocampus, but the competing multiple trace/trace transformation theories posit indefinite involvement. Lesion evidence remains inconclusive, and the inferences one can draw from functional MRI (fMRI) have been limited by reliance on covert (silent) recall, which obscures dynamic, moment-to-moment content of retrieved memories. Here, we capitalized on advances in fMRI denoising to employ overtly spoken recall. Forty participants retrieved recent and remote memories, describing each for approximately 2 min. Details associated with each memory were identified and modeled in the fMRI time-series data using a variant of the Autobiographical Interview procedure, and activity associated with the recall of recent and remote memories was then compared. Posterior hippocampal regions exhibited temporally graded activity patterns (recent events > remote events), as did several regions of frontal and parietal cortex. Consistent with predictions of the standard model, recall-related hippocampal activity differed from a non-autobiographical control task only for recent, and not remote, events. Task-based connectivity between posterior hippocampal regions and others associated with mental scene construction also exhibited a temporal gradient, with greater connectivity accompanying the recall of recent events. These findings support predictions of the standard model of consolidation and demonstrate the potential benefits of overt recall in neuroimaging experiments.
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