Evidence map›Paper›PMID 33723066›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Testosterone reduces generosity through cortical and subcortical mechanisms.

Jianxin Ou, Yin Wu, Yang Hu, Xiaoxue Gao, Hong Li, Philippe N Tobler

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 41 citations in OpenAlex.

  1. Testosterone eliminates strategic prosocial behavior through impacting choice consistency in healthy males.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Trial
  2. Article
  3. Article
  4. Article
  5. The social transmission of empathy relies on observational reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Prostate cancer treatment and the relationship of androgen deprivation therapy to cognitive function.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Jianxin OuSchool of Psychology, Shenzhen University, 518060 Shenzhen, China.ORCID 0000-0003-4934-3736
Yin WuSchool of Psychology, Shenzhen University, 518060 Shenzhen, China; yinwu0407@gmail.com lihongwrm@vip.sina.com.ORCID 0000-0002-6364-4597
Yang HuSchool of Psychological and Cognitive Sciences, Peking University, 100871 Beijing, China.
Xiaoxue GaoSchool of Psychological and Cognitive Sciences, Peking University, 100871 Beijing, China.ORCID 0000-0001-8901-6137
Hong LiSchool of Psychology, South China Normal University, 510631 Guangzhou, China; yinwu0407@gmail.com lihongwrm@vip.sina.com.
Philippe N ToblerZurich Center for Neuroeconomics, Department of Economics, University of Zurich, 8006 Zürich, Switzerland.ORCID 0000-0002-4915-9448
Shenzhen University · CNPeking University · CNShanghai International Studies University · CNSouth China Normal University · CNUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence has linked testosterone, a major sex hormone, to selfishness in economic decision-making. Here, we aimed to investigate the neural mechanisms through which testosterone reduces generosity by combining functional MRI with pharmacological manipulation among healthy young males in a double-blind, placebo-controlled, between-subject design. After testosterone or placebo gel administration, participants performed a social discounting task in which they chose between selfish options (benefiting only the participant) and generous options (providing also some benefit to another person at a particular social distance). At the behavioral level, testosterone reduced generosity compared to the placebo. At the neural level (

Indexed as

Brain MappingCase-Control StudiesCerebral CortexDecision MakingHumansMagnetic Resonance ImagingMalePersonalitySocial BehaviorTestosteroneTestosteronealtruistic preferencesandrogenprosocial behaviorsocial cognitiontemporoparietal junction

Identifiers

PMID33723066
PMCPMC8000274
OpenAlexW3137943348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.