Evidence map›Paper›PMID 33723058›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant

Chelsey M VanDrisse, Rosalie Lipsh-Sokolik, Olga Khersonsky, Sarel J Fleishman, Dianne K Newman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Unlocking the potential ofFrontiers in microbiology · 2026
    Article
  3. Factors governing the response ofFrontiers in cellular and infection microbiology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Addressing epistasis in the design of protein function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition ofbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. The chemical ecology of coumarins and phenazines affects iron acquisition by pseudomonads.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Assessing and enhancing foldability in designed proteins.Protein science : a publication of the Protein Society · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chelsey M VanDrisseDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0001-9139-0443
Rosalie Lipsh-SokolikDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel 7610001.ORCID 0000-0002-5548-7309
Olga KhersonskyDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel 7610001.
Sarel J FleishmanDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel 7610001; sarel.fleishman@weizmann.ac.il dkn@caltech.edu.ORCID 0000-0003-3177-7560
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; sarel.fleishman@weizmann.ac.il dkn@caltech.edu.

Funding

Biological mechanisms and consequences of efficient extracellular electron transfer in Pseudomonas aeruginosaR01AI127850 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Dianne K Newman · 2017 to 2026
$5.6M
Testing the hypothesis that microbial energetic hijacking of the CF immune response selects for specific pathogens during lung function decline- Diversity SupplementR01HL152190 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NEWMAN, DIANNE K · 2020 to 2023
$2.0M
NHLBI NIH HHS R01 HL152190NIAID NIH HHS R01 AI127850
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiofilmsDrug DesignDrug SynergismHumansOxidoreductases, N-DemethylatingProtein EngineeringPseudomonas aeruginosaPyocyanineTobramycinOxidoreductases, N-DemethylatingPyocyanineTobramycinAffiLibantibiotic tolerancebiofilmsPseudomonas aeruginosapyocyanin

Identifiers

PMID33723058
PMCPMC8000102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.