Evidence map›Paper›PMID 33722961›Full record

ArticleJournal of neurointerventional surgery2022

Pivotal trial of the Neuroform Atlas stent for treatment of posterior circulation aneurysms: one-year outcomes.

Brian T Jankowitz, Ashutosh P Jadhav, Bradley Gross, Tudor G Jovin, Abdulnasser A Alhajeri, Justin F Fraser, Ricardo A Hanel, Eric Sauvageau, Amin Aghaebrahim, Donald Frei and 27 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Journal of neurointerventional surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  12. Stretched and fractured Neuroform AtlasExperimental and therapeutic medicine · 2023
    Article
  13. [Clinical application of Neuroform Atlas stent-assisted coiling in the treatment of unruptured wide-neck intracranial aneurysms].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 5 countries.

Brian T JankowitzCooper Neurological Institute, Cooper University Hospital, Camden, New Jersey, USA jankowitz-brian@cooperhealth.edu.
Ashutosh P JadhavBarrow Neurological Institute, Phoenix, Arizona, USA.
Bradley GrossDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Tudor G JovinDepartment of Neurology, Cooper University Hospital, Camden, New Jersey, USA.
Abdulnasser A AlhajeriDepartment of Diagnostic Radiology, Riverside Radiology and Interventional Associates Inc, Columbus, Ohio, USA.
Justin F FraserDepartment of Neurological Surgery, University of Kentucky, Lexington, Kentucky, USA.ORCID http://orcid.org/0000-0002-5980-3989
Ricardo A HanelBaptist Health System Jacksonville, Jacksonville, Florida, USA.ORCID http://orcid.org/0000-0001-7195-5806
Eric SauvageauLyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA.
Amin AghaebrahimNeurological Institute, Lyerley Neurosurgery, Baptist Medical Center Jacksonville, Jacksonville, Florida, USA.ORCID http://orcid.org/0000-0002-9126-2932
Donald FreiDepartment of Interventional Neuroradiology, Radiology Imaging Associates, Englewood, Colorado, USA.ORCID http://orcid.org/0000-0002-7811-5030
Richard BellonDepartment of Interventional Neuroradiology, Radiology Imaging Associates, Englewood, Colorado, USA.
David LoyDepartment of Radiology, University of Virginia Medical Center, Charlottesville, Virginia, USA.
Ajit S PuriDepartment of Radiology, University of Massachusetts, Worcester, Massachusetts, USA.
Adel M MalekDepartment of Neurosurgery, Tufts Medical Center, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-0642-7609
Ajith ThomasDepartment of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0003-4412-3152
Gabor TothCerebrovascular Center, Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3646-3635
Demetrius Klee LopesBrain and Spine Institute, Advocate Aurora Health, Park Ridge, Illinois, USA.ORCID http://orcid.org/0000-0002-6280-0113
R Webster CrowleyRush University, Chicago, Illinois, USA.
Adam S ArthurSemmes-Murphey Neurologic and Spine Institute, Memphis, Tennessee, USA.ORCID http://orcid.org/0000-0002-1536-1613
John Reavey-CantwellVirginia Commonwealth University, Richmond, Virginia, USA.
Eugene LinNeuroscience Department, Mercy Health St Vincent Medical Center Department of Internal Medicine, Toledo, Ohio, USA.
Adnan H SiddiquiDepartment of Neurosurgery, University at Buffalo, Buffalo, New York, USA.
Michael J AlexanderDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-0280-809X
Ahmad KhaldiDepartment of Neurosurgery, Wellstar Health System, Marietta, Georgia, USA.
Geoffrey P ColbyDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-3376-0933
Justin M CaplanDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-0289-3661
Sudhakar R SattiDepartment of Neurointerventional Surgery, CCHS, Newark, Delaware, USA.
Aquilla S TurkDepartment of Neuroradiology, Prisma Helath, Greenville, South Carolina, USA.
Alejandro M SpiottaDepartment of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Richard KlucznikDivision of Interventional Neuroradiology, Houston Methodist Hospital, Houston, Texas, USA.
Danial K HallamDepartment of Radiology, University of Washington, Seattle, Washington, USA.
David KungDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-1387-6082
Michael T FroehlerCerebrovascular Program, Vanderbilt University, Nashville, Tennessee, USA.
R Charles CallisonDepartment of Interventional Neurology, Lawnwood Regional Medical Center and Heart Institute, Fort Pierce, Florida, USA.
Peter KanDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.ORCID http://orcid.org/0000-0001-6649-4128
Steven W HettsDepartment of Radiology, UCSF, San Francisco, California, USA.ORCID http://orcid.org/0000-0001-5885-7259
Osama O ZaidatDepartment of Neuroscience, St Vincent Mercy Hospital, Toledo, Ohio, USA.ORCID http://orcid.org/0000-0003-4881-4698
Cooper University Hospital · USRadiology Associates · USAdvocate Health Care · USBaptist Cancer Center · USBaptist Health System · USBaptist Medical Center Jacksonville · USBarrow Neurological Institute · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USCalifornia University of Pennsylvania · USCedars-Sinai Medical Center · USCleveland Clinic · USJohns Hopkins University · USLakewood Regional Medical Center · USMedical University of South Carolina · USMercy Medical Center · USMercy St. Vincent Medical Center · USPrisma Health · USRush University · USSociety of Interventional Radiology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results.

objectiveTo present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs.

methodsThe ATLAS trial is a prospective, multicenter, single-arm, open-label study of unruptured, wide-necked, IAs treated with the Atlas stent and adjunctive coiling. This study reports the results of patients with posterior circulation IAs. The primary efficacy endpoint was complete aneurysm occlusion (Raymond-Roy (RR) class I) on 12-month angiography, in the absence of re-treatment or parent artery stenosis >50%. The primary safety endpoint was any major ipsilateral stroke or neurological death within 12 months. Adjudication of the primary endpoints was performed by an imaging core laboratory and a Clinical Events Committee.

resultsThe ATLAS trial enrolled and treated 116 patients at 25 medical centers with unruptured, wide-necked, posterior circulation IAs (mean age 60.2±10.5 years, 81.0% (94/116) female). Stents were placed in all patients with 100% technical success rate. A total of 95/116 (81.9%) patients had complete angiographic follow-up at 12 months, of whom 81 (85.3%) had complete aneurysm occlusion (RR class I). The primary effectiveness outcome was achieved in 76.7% (95% CI 67.0% to 86.5%) of patients. Overall, major ipsilateral stroke and secondary persistent neurological deficit occurred in 4.3% (5/116) and 1.7% (2/116) of patients, respectively.

conclusionsIn the ATLAS IDE posterior circulation cohort, the Neuroform Atlas Stent System with adjunctive coiling demonstrated high rates of technical and safety performance.

Indexed as

Embolization, TherapeuticIntracranial AneurysmAgedCerebral AngiographyFemaleHumansMiddle AgedProspective StudiesRetrospective StudiesStentsTreatment Outcomeaneurysmcoilstent

Identifiers

PMID33722961
PMCPMC8785011
OpenAlexW3136757196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.