Evidence map›Paper›PMID 33722957›Full record

ReviewDevelopment (Cambridge, England)2021

Mammalian primordial germ cell specification.

Grace V Hancock, Sissy E Wamaitha, Lior Peretz, Amander T Clark

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Mechanisms of human germ cell development.Nature reviews. Molecular cell biology · 2026
    Review
  11. Article
  12. Review
  13. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Stem cell-based models of early human development.Development (Cambridge, England) · 2025
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Grace V HancockDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Sissy E WamaithaDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Lior PeretzDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Amander T ClarkDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA clarka@ucla.edu.ORCID 0000-0003-2483-3982
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Understanding Epigenetic Remodeling in Primordial Germ CellsR01HD058047 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2009 to 2023
$5.6M
Differentiating embryonic stem cells into developing germ lineR01HD079546 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2015 to 2024
$3.7M
Towards a preclinical model for overcoming infertility with induced pluripotent stem cellsR01HD098278 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2019 to 2023
$3.0M
NCATS NIH HHS UL1 TR001881NICHD NIH HHS R01 HD058047NICHD NIH HHS R01 HD079546NICHD NIH HHS R01 HD098278
6 · The paper itself

Abstract

The peri-implantation window of mammalian development is the crucial window for primordial germ cell (PGC) specification. Whereas pre-implantation dynamics are relatively conserved between species, the implantation window marks a stage of developmental divergence between key model organisms, and thus potential variance in the cell and molecular mechanisms for PGC specification. In humans, PGC specification is very difficult to study

Indexed as

AnimalsCell DifferentiationDNA MethylationEmbryonic DevelopmentEmbryonic Stem CellsGerm CellsHumansModels, BiologicalX ChromosomeEmbryoGerm cellsImplantationPeri-implantationPluripotencyPrimordial germ cells

Identifiers

PMID33722957
PMCPMC7990907
OpenAlexW3137167906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.