Evidence map›Paper›PMID 33722892›Full record

ArticleAntimicrobial agents and chemotherapy2021

Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests.

E Ardizzoni, E Ariza, D Mulengwa, Q Mpala, R de La Tour, G Maphalala, F Varaine, B Kerschberger, P Graulus, A L Page and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Clinical standards for drug-susceptible pulmonary TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  8. Evolution ofFrontiers in cellular and infection microbiology · 2022
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 6 countries.

E ArdizzoniInstitute of Tropical Medicine, Antwerp, Belgium eardizzoni@itg.be.ORCID 0000-0003-3562-9194
E ArizaInfectious Diseases Service, Hospital Clinic-IDIBAPS, Barcelona, Spain.
D MulengwaMédecins Sans Frontières, Mbabane, Eswatini.
Q MpalaMédecins Sans Frontières, Mbabane, Eswatini.
R de La TourMédecins Sans Frontières, Geneva, Switzerland.
G MaphalalaMinistry of Health (NRL), Mbabane, Eswatini.
F VaraineMédecins Sans Frontières, Paris, France.
B KerschbergerMédecins Sans Frontières, Geneva, Switzerland.
P GraulusInstitute of Tropical Medicine, Antwerp, Belgium.
A L PageEpicentre, Paris, France.
S NiemannMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
V DreyerMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
A Van DeunInstitute of Tropical Medicine, Antwerp, Belgium.
T DecrooInstitute of Tropical Medicine, Antwerp, Belgium.
L RigoutsInstitute of Tropical Medicine, Antwerp, Belgium.
B C de JongInstitute of Tropical Medicine, Antwerp, Belgium.
Instituut voor Tropische Geneeskunde · BEGerman Center for Infection Research · DEMédecins Sans Frontières · CHSouthern Africa Nazarene University · SZHospital Clínic de Barcelona · ESMédecins Sans Frontières · FRMinistry of Health · SZResearch Foundation - Flanders · BEUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xpert MTB/RIF rapidly detects resistance to rifampicin (RR); however, this test misses I491F-RR conferring

Indexed as

Antibiotics, AntitubercularMycobacterium tuberculosisPharmaceutical PreparationsTuberculosis, Multidrug-ResistantAgarDiagnostic Tests, RoutineDrug Resistance, BacterialEswatiniHumansMicrobial Sensitivity TestsRifampinSensitivity and SpecificitySputumWorld Health OrganizationAgarAntibiotics, AntitubercularPharmaceutical PreparationsRifampinMDRresistance detectionrpoB I491F mutantTLAtuberculosisXDRXpert MTB/RIF

Identifiers

PMID33722892
PMCPMC8315964
OpenAlexW3138100970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.