Evidence map›Paper›PMID 33722890›Full record

ArticleAntimicrobial agents and chemotherapy2021

Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis.

Samuel J Modlin, Tyler Marbach, Jim Werngren, Mikael Mansjö, Sven E Hoffner, Faramarz Valafar

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Enhancing diagnostic efficiency of pyrazinamide resistance inCurrent research in microbial sciences · 2025
    Article
  5. Review
  6. Bacterial persisters: molecular mechanisms and therapeutic development.Signal transduction and targeted therapy · 2024
    Review
  7. Phenotypic and genotypic characterization ofFrontiers in microbiology · 2024
    Article
  8. Review
  9. Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Samuel J ModlinLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.
Tyler MarbachLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.
Jim WerngrenDepartment of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
Mikael MansjöDepartment of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
Sven E HoffnerLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.
Faramarz ValafarLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA faramarz@sdsu.edu.ORCID 0000-0002-3648-9384
San Diego State University · USPublic Health Agency of Sweden · SE

Funding

Evolutionary and Functional Significance of Novel Mutations in MDR-XDR TBR01AI105185 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2013 to 2021
$5.3M
Undetected Drug resistance and Tolerance in lesions of recurrent TBR01AI163202 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2022 to 2025
$2.8M
NIAID NIH HHS R01 AI105185NIAID NIH HHS R01 AI163202
6 · The paper itself

Abstract

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAmidohydrolasesAntitubercular AgentsDrug Resistance, BacterialHumansMicrobial Sensitivity TestsMutationPhylogenyPyrazinamideSwedenAmidohydrolasesAntitubercular AgentsPyrazinamideantibiotic resistanceantimicrobial resistanceclpC1low-level resistancemode of actionmonoresistanceMycobacterium tuberculosispncApyrazinamidepyrazinamide resistance

Identifiers

PMID33722890
PMCPMC8315952
OpenAlexW3137875265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.