Evidence map›Paper›PMID 33722866›Full record

Trial reportBMJ open2021

Effect of free distribution of medicines on the process of care for adult patients with type 1 and type 2 diabetes and hypertension: post hoc analysis of randomised controlled trial findings.

Onella Charles, Hannah Woods, Muhamad Ally, Braden Manns, Baiju R Shah, Ri Wang, Nav Persaud

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02744963 (Carefully seLected and Easily Accessible at No Charge Medications), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02744963 naunknown statusnot on this map

Carefully seLected and Easily Accessible at No Charge Medications

TypeinterventionalSponsorUnity Health TorontoRan2016 to 2020Enrolled784ConditionsMedication Adherence, Inappropriate Prescribing, Diabetes, HypertensionArmsFree and convenient medicine access
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Onella CharlesFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Hannah WoodsMAP Centre for Urban Health Solutions, St Michael's Hospital, Toronto, Ontario, Canada.
Muhamad AllyMAP Centre for Urban Health Solutions, St Michael's Hospital, Toronto, Ontario, Canada.
Braden MannsDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Baiju R ShahInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Ri WangMAP Centre for Urban Health Solutions, St Michael's Hospital, Toronto, Ontario, Canada.
Nav PersaudMAP Centre for Urban Health Solutions, St Michael's Hospital, Toronto, Ontario, Canada nav.persaud@utoronto.ca.ORCID http://orcid.org/0000-0003-3327-5580
St. Michael's Hospital · CASunnybrook Health Science Centre · CAUniversity of Calgary · CA

Funding

Canadian Institutes for Health Research 381409
6 · The paper itself

Abstract

objectivesThe Carefully Selected and Easily Accessible at No charge Medicines randomised controlled trial showed that patients receiving free access to medicines had improved diabetes and hypertension outcomes compared with patients who had usual access to medicines. In this study, we aimed to test the impact of providing free access to medicine to people with diabetes and hypertension on process of care indicators.

designIn this post hoc analysis of randomised controlled trial findings, we identified process of care indicators for the management of diabetes and hypertension using relevant guidelines. The following process of care indicators were identified for diabetes management: encounters with healthcare professionals, blood pressure measurements, self-monitoring of blood glucose, annual eye and foot examination, annual administration of the influenza vaccine, and laboratory testing for glycated haemoglobin (HbA1c), low-density lipoprotein-cholesterol, serum creatinine and urine albumin to creatinine ratio. We identified the following process of care indicators for hypertension: encounters with healthcare professionals, blood pressure measurements, self-measuring of blood pressure, and serum tests for electrolytes, HbA1c, lipids and creatinine. Chart extractions were performed for all patients and the indicators for diabetes and hypertension were recorded. We compared the indicators for patients in each arm of the trial.

resultsThe study included 268 primary care patients. Free distribution of medicines may improve self-monitoring behaviours (adjusted rate ratio (aRR) 1.30; 95% CI 0.66 to 2.57) and reduce missed primary care appointments for patients with diabetes (aRR 0.80; 95% CI 0.48 to 1.33) or hypertension (aRR 0.41; 95% CI 0.18 to 0.90). Free distribution may also reduce primary care and consultant appointments and laboratory testing in patients with hypertension.

conclusionsImproving medicine accessibility for patients with diabetes and hypertension not only improves surrogate health outcomes but also improves the patient experience and may also reduce healthcare costs by encouraging self-monitoring. TRIAL REGISTRATION NUMBER: The randomised controlled trial mentioned is clinicaltrials.gov identifier: NCT02744963.

Indexed as

Diabetes Mellitus, Type 2HypertensionAdultBlood GlucoseGlycated HemoglobinHumansPrimary Health CareBlood GlucoseGlycated Hemoglobindiabetes & endocrinologyhealth policyprimary care

Identifiers

PMID33722866
PMCPMC7959224
OpenAlexW3138472469

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.