ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Peculiar clinical presentation of COVID-19 and predictors of mortality in the elderly: A multicentre retrospective cohort study.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- The prognostic value of Clinical Frailty Scale in COVID-19 pneumonia across different pandemic phases: a comparison between the first and the fourth wave.Frontiers in medicine · 2025Article
- Clinical Manifestations and Outcomes of Older Patients with COVID-19: A Comprehensive Review.Tuberculosis and respiratory diseases · 2024Article
- Retrospective study of factors associated with the clinical severity of covid-19 in older adults in Minas Gerais: structural equation modeling.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Risk factors and outcomes of delirium in hospitalized older adults with COVID-19: A systematic review and meta-analysis.Aging and health research · 2023Review
- The global case fatality rate due to COVID-19 in hospitalized elderly patients by sex, year, gross domestic product, and continent: A systematic review, meta-analysis, and meta-regression.New microbes and new infections · 2023Review
- Clinical Features of SARS-CoV-2 Infection in Older Adults.Clinics in geriatric medicine · 2022Review
- Clinical Frailty Scale (CFS) indicated frailty is associated with increased in-hospital and 30-day mortality in COVID-19 patients: a systematic review and meta-analysis.Annals of intensive care · 2022Article
- Efficacy and safety of oral antivirals in individuals aged 80 years or older with mild-to-moderate COVID-19: preliminary report from an Italian Prescriber Center.Le infezioni in medicina · 2022Article
- Association between Prehospital Hypoxemia and Admission to Intensive Care Unit during the COVID-19 Pandemic: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2021Article
- A retrospective analysis of 902 hospitalized COVID-19 patients in Lebanon: clinical epidemiology and risk factors.Journal of clinical virology plus · 2021Article
- Comparison of Clinical Characteristics and Outcomes of Younger and Elderly Patients with Severe COVID-19 in Korea: A Retrospective Multicenter Study.Journal of personalized medicine · 2021Article
- Hormonal Contraception and Massive Pulmonary Embolism in a COVID-19 Ambulatory Patient: A Case Report.Clinics and practice · 2021Article
- Challenges in Steroid and Anticoagulant Therapy in Severe COVID-19 Pneumonia: A Prospective Study.Antibiotics (Basel, Switzerland) · 2021Article
- Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection.Journal of clinical medicine · 2021Article
- Hypophosphatemia at Admission is Associated with Increased Mortality in COVID-19 Patients.International journal of general medicine · 2021Article
- Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis.Gerontology & geriatric medicineReview
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe spectrum of COVID-19 clinical manifestations is not yet known. In the elderly, mortality and extrapulmonary involvement appears more frequent than expected.
methodsA multicentre-retrospective-case-series study of COVID-19 patients, aged ≥65 years, hospitalised between March 1 and June 15, 2020. Patients were classified at admission into 3 groups based on their Clinical Frailty Scale (CFS) score: 1-3 (group A), 4-6 (group B) and 7-9 (group C).
resultsOf the 206 patients in the study, 60 (29%) were assigned to group A, 60 (29%) to B and 86 (42%) to C. Significantly more frequent in group C than in B or A were: mental confusion (respectively 65%, 33%, 7%; P < 0.001), kidney failure (39%, 22%, 20%; P = 0.019), dehydration syndrome (55%, 27%, 13%; P < 0.001), electrolyte imbalance (54%, 32%, 25%; P = 0.001), and diabetic decompensation (22%, 12%, 7%; P = 0.026). Crude mortality was 27%. By multivariate logistic regression model independent predictors of death were male sex (adjusted odds ratio (aOR) = 2.87,95%CI = 1.15-7.18), CFS 7-9 (aOR = 9.97,95%CI = 1.82-52.99), dehydration at admission (aOR = 4.27,95%CI = 1.72-10.57) and non-invasive/invasive ventilation (aOR = 4.88,95%CI = 1.94-12.26).
conclusionsElderly patients with a high CFS showed frequent extrapulmonary signs at admission, even in the absence of lung involvement. These findings, along with a high CFS, predicted a significant risk of mortality.
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