Evidence map›Paper›PMID 33722616›Full record

ReviewNeuroscience and biobehavioral reviews2021

Understanding the dynamic and destiny of memories.

Lucas de Oliveira Alvares, Fabricio H Do-Monte

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lucas de Oliveira AlvaresNeurobiology of Memory Laboratory, Biophysics Department, Biosciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, RS, 91509-900, Brazil. Electronic address: lucas.alvares@ufrgs.br.
Fabricio H Do-MonteDepartment of Neurobiology and Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, United States. Electronic address: fabricio.h.domonte@uth.tmc.edu.

Funding

Neural Circuits Balancing Reward-Approaching with Threat-AvoidanceR01MH120136 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DO MONTE, FABRICIO HOFFMANN · 2020 to 2024
$2.8M
Thalamic circuits in the integration of fear and rewardR00MH105549 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DO MONTE, FABRICIO HOFFMANN · 2016 to 2018
$747k
Thalamic circuits in the integration of fear and rewardK99MH105549 · NIMH · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI DO MONTE, FABRICIO HOFFMANN · 2015 to 2016
$137k
NIMH NIH HHS K99 MH105549NIMH NIH HHS R00 MH105549NIMH NIH HHS R01 MH120136
6 · The paper itself

Abstract

Memory formation enables the retention of life experiences overtime. Based on previously acquired information, organisms can anticipate future events and adjust their behaviors to maximize survival. However, in an ever-changing environment, a memory needs to be malleable to maintain its relevance. In fact, substantial evidence suggests that a consolidated memory can become labile and susceptible to modifications after being reactivated, a process termed reconsolidation. When an extinction process takes place, a memory can also be temporarily inhibited by a second memory that carries information with opposite meaning. In addition, a memory can fade and lose its significance in a process known as forgetting. Thus, following retrieval, new life experiences can be integrated with the original memory trace to maintain its predictive value. In this review, we explore the determining factors that regulate the fate of a memory after its reactivation. We focus on three post-retrieval memory destinies (reconsolidation, extinction, and forgetting) and discuss recent rodent studies investigating the biological functions and neural mechanisms underlying each of these processes.

Indexed as

MemoryExtinctionForgettingMemory updatingReconsolidationRetrieval

Identifiers

PMID33722616
PMCPMC8783376

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.