Evidence map›Paper›PMID 33722515›Full record

ReviewBiochimica et biophysica acta. Bioenergetics2021

Metabolic implications of non-electrogenic ATP/ADP exchange in cancer cells: A mechanistic basis for the Warburg effect.

John J Lemasters

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Bioenergetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
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  3. Review
  4. Article
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  6. Review
  7. Review
  8. Review
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  12. Sperm-Induced CaCells · 2023
    Review
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  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

John J LemastersCenter for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States of America. Electronic address: JJLemasters@musc.edu.
Medical University of South Carolina · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hailong Zhang · 2020 to 2026
$18.7M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and TherapyR01DE016572 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI OGRETMEN, BESIM · 2005 to 2025
$7.4M
Mitochondrial depolarization, mitophagy, and mitochondrial DAMPs in ALDR01AA025379 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ZHI ZHONG · 2018 to 2026
$3.8M
Mitochondria-Mediated Effects and Therapeutic Potential of Atrial Natriuretic Peptide in Salt-Sensitive Hypertension Diversity SupplementR01HL148114 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ILATOVSKAYA, DARIA · 2020 to 2024
$2.8M
Understanding Metabolic and Epigenetic Cross‐ talk in Potent Anti‐ tumor T cellsR01CA250458 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEHROTRA, SHIKHAR · 2020 to 2024
$2.3M
Study and Treatment of Mitochondrial DNA Depletion Syndrome 3 Using iPSCsR01DK119728 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUNCAN, STEPHEN A · 2019 to 2022
$2.0M
Mechanisms of Mitochondrial Iron Uptake: New Therapeutic Targets in HepatotoxicityR01DK119523 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J, NIEMINEN, ANNA-LIISA · 2021 to 2024
$1.8M
NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA250458NHLBI NIH HHS R01 HL148114NIAAA NIH HHS R01 AA021191NIAAA NIH HHS R01 AA025379NIAAA NIH HHS R01 AA027532NIDCR NIH HHS R01 DE016572NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK119523NIDDK NIH HHS R01 DK119728NIEHS NIH HHS R21 ES031335NIGMS NIH HHS P20 GM103542NIGMS NIH HHS P20 GM130457NIGMS NIH HHS R01 GM137578NIH HHS S10 OD018113
6 · The paper itself

Abstract

In post-mitotic cells, mitochondrial ATP/ADP exchange occurs by the adenine nucleotide translocator (ANT). Driven by membrane potential (ΔΨ), ANT catalyzes electrogenic exchange of ATP

Indexed as

Energy MetabolismGlycolysisOxygen ConsumptionWarburg Effect, OncologicAdenosine DiphosphateAdenosine TriphosphateHumansNeoplasmsOxidation-ReductionAdenosine DiphosphateAdenosine TriphosphateAerobic glycolysisATP/ADP exchangeCancerGlutamineMitochondriaWarburg effect

Identifiers

PMID33722515
PMCPMC8096716
OpenAlexW3136795851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.