SynthesisVaccine2021
International estimates of intended uptake and refusal of COVID-19 vaccines: A rapid systematic review and meta-analysis of large nationally representative samples.
Synthesis in Vaccine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 323 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
323 citing papers in PubMed, 14 syntheses or guidelines pooled it, 523 citations in OpenAlex.
- Racial and ethnic disparities in COVID-19 vaccination: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2025Pooled it
- Prior infections and effectiveness of SARS-CoV-2 vaccine in test-negative studies: a systematic review and meta-analysis.American journal of epidemiology · 2024Pooled it
- Vaccine hesitancy in context of COVID-19 in East Africa: systematic review and meta-analysis.BMC public health · 2024Pooled it
- COVID-19 Vaccine Acceptance and Hesitancy among People Living with HIV: Review and Meta-Analysis.AIDS and behavior · 2024Pooled it
- COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis.JMIR public health and surveillance · 2024Pooled it
- A systematic review and meta-analysis of the global prevalence and determinants of COVID-19 vaccine acceptance and uptake in people living with HIV.Nature human behaviour · 2024Pooled it
- COVID-19 vaccination intention among nursing, medical, and dental students: A systematic review and meta-regression analysis.Human vaccines & immunotherapeutics · 2023Pooled it
- Predictors of COVID-19 vaccination hesitancy in China: a meta-analysis.Public health · 2023Pooled it
- Implications for COVID-19 vaccine uptake: A systematic review.Journal of infection and public health · 2023Pooled it
- The determinants of COVID-19 vaccination intention: a meta-review.Frontiers in public health · 2023Pooled it
- Prevalence and factors related to COVID-19 vaccine hesitancy and unwillingness in Canada: A systematic review and meta-analysis.Journal of medical virology · 2023Pooled it
- Attitudes of COVID-19 vaccination among college students: A systematic review and meta-analysis of willingness, associated determinants, and reasons for hesitancy.Human vaccines & immunotherapeutics · 2022Pooled it
- Hesitancy of COVID-19 vaccines: Rapid systematic review of the measurement, predictors, and preventive strategies.Human vaccines & immunotherapeutics · 2022Pooled it
- Factors associated with COVID-19 vaccine intentions during the COVID-19 pandemic; a systematic review and meta-analysis of cross-sectional studies.BMC public health · 2022Pooled it
- Sociodemographic and Lifestyle Factors Associated With COVID-19 Vaccine Uptake in a Mixed Urban-Rural Population in Eastern Poland.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Predictors of COVID-19 vaccination status: a nationwide linkage study in Czechia.Journal of public health (Oxford, England) · 2026Article
- Vaccine acceptance in a future pandemic after COVID-19 and its decision drivers in Japan.NPJ vaccines · 2026Article
- Long-term Cardiovascular Outcomes in US Medicare Beneficiaries After COVID-19 Hospitalization During the Omicron Era.Circulation. Population health and outcomes · 2026Article
- Factors Associated with Human Papillomavirus Vaccination Intention Among Young Men in Japan: A Cross-Sectional Study.Journal of community health · 2026Article
- Determinants and Dynamics of COVID-19 Vaccine Hesitancy in University Students: A Machine Learning Analysis.Vaccines · 2026Article
263 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWidespread uptake of COVID-19 vaccines will be essential to controlling the COVID-19 pandemic. Vaccines have been developed in unprecedented time and quantifying levels of hesitancy towards vaccination among the general population is of importance.
methodsSystematic review and meta-analysis of studies using large nationally representative samples (n ≥ 1000) to examine the percentage of the population intending to vaccinate, unsure, or intending to refuse a COVID-19 vaccine when available. Generic inverse meta-analysis and meta-regression were used to pool estimates and examine time trends. PubMed, Scopus and pre-printer servers were searched from January-November 2020. Registered on PROSPERO (CRD42020223132).
findingsTwenty-eight nationally representative samples (n = 58,656) from 13 countries indicate that as the pandemic has progressed, the percentage of people intending to vaccinate decreased and the percentage of people intending to refuse vaccination increased. Pooled data from surveys conducted during June-October suggest that 60% (95% CI: 49% to 69%) intend to vaccinate and 20% (95% CI: 13% to 29%) intend to refuse vaccination, although intentions vary substantially between samples and countries (I
interpretationIntentions to be vaccinated when a COVID-19 vaccine becomes available have been declining across countries and there is an urgent need to address social inequalities in vaccine hesitancy and promote widespread uptake of vaccines as they become available.
fundingN/A.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.