Evidence map›Paper›PMID 33722300›Full record

ArticleBMC chemistry2021

A novel zinc complex with antibacterial and antioxidant activity.

Yun Zhang, Xiaojing Li, Jia Li, Md Zaved Hossain Khan, Fanyi Ma, Xiuhua Liu

Open access · goldAbstract read
In one paragraph

Article in BMC chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 40 citations in OpenAlex.

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  8. Functionalities ofMolecules (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yun Zhang *Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, School of Pharmacy, Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
Xiaojing Li *Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, School of Pharmacy, Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
Jia LiKey Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, School of Pharmacy, Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
Md Zaved Hossain KhanDepartment of Chemical Engineering, Jashore University of Science and Technology, Jahsore, 7408, Bangladesh.
Fanyi MaKey Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, School of Pharmacy, Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China. fanyima@126.com.
Xiuhua LiuKey Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, School of Pharmacy, Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China. liuxiuhua@henu.edu.cn.
Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn order to enhance the antibacterial activity and reduce the toxicity of Zn

resultsA water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl

conclusionsThe results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.

Indexed as

Antibacterial activityCharacterizationFluorescenceSynthesisZinc-glucose-citrate complex

Identifiers

PMID33722300
PMCPMC7962405
OpenAlexW3138746760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.