ReviewJournal of cannabis research2021
The biosynthesis of the cannabinoids.
Review in Journal of cannabis research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 83 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed.
- X-ray crystal structures of the cannabinoid synthases CBCAS, CBDAS and THCAS.Current research in structural biology · 2026Article
- Cannabigerol at the Interface of the Gut Microbiota and EndoCannabinoidome: Mechanistic Insights into Inflammation and Pain Modulation.Medical sciences (Basel, Switzerland) · 2026Review
- Neuropharmacology of Cannabinoids: A Comprehensive Review of Preclinical and Clinical Evidence for Hemp-Derived Extracts and Active Compounds.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Structure-stability relationships of pure cannabinoids and their cocrystals under forced degradation conditions.Journal of cannabis research · 2026Article
- Cold plasma, Fe and Mn nanoparticles modulate antioxidant activity, cannabinoids gene expression, and fatty acid profile in salt-stressed hemp.Scientific reports · 2026Article
- Heads Up: Transcriptomics Reveal Functional Roles of Cannabis Glandular Trichome Stalks.Plants (Basel, Switzerland) · 2026Article
- Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration.Journal of cannabis research · 2026Review
- Anti-Neuroinflammatory Cannabinoid Acids as a New Therapeutic Approach for Multiple Sclerosis.Molecules (Basel, Switzerland) · 2026Article
- Cannabis: from crop to shop-some insights about stability to access quality control.Journal of cannabis research · 2026Review
- Therapeutic potential of acidic cannabinoids: an update.Journal of cannabis research · 2026Review
- Nemophilosides A-I, nine meroterpenoid glucosides isolated from Nemophila menziesii.Journal of natural medicines · 2026Article
- Kendrick Mass Defect Filtering Enables High-Throughput Untargeted Annotation of Minor Phytocannabinoids: Toward Streamlined Phytocannabinomics.ACS measurement science au · 2025Article
- From deficiency to toxicity: Magnesium increases cannabinoid and terpene production in cannabis plants.Journal of cannabis research · 2025Article
- Influence of Agronomic Practices on the Bioactive Compound Production inInternational journal of molecular sciences · 2025Article
- Identification of Three Novel Tetrahydrocannabinol Analogs in the European Market.Drug testing and analysis · 2025Article
- Isolating and Determining the Structures of Colored Products from the Reactions of Cannabinoids with Fast Blue RR.Molecules (Basel, Switzerland) · 2025Article
- Correction: The biosynthesis of the cannabinoids.Journal of cannabis research · 2025Article
- Haploid Production inBiology · 2025Review
- Assessing the adaptive role of cannabidivarinic acid (CBDVA) in aphid defense in Cannabis sativa.Journal of cannabis research · 2025Article
- Characterization and functional reconstruction of a highly productive germacrene A synthase from Liriodendron chinense.Plant biotechnology journal · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engineer strains with specific cannabinoid profiles. This review surveys the biosynthesis and biochemistry of cannabinoids. The pathways and the enzymes' mechanisms of action are discussed as is the non-enzymatic decarboxylation of the cannabinoic acids. There are still many gaps in our knowledge about the biosynthesis of the cannabinoids, especially for the minor components, and this review highlights the tools and approaches that will be applied to generate an improved understanding and consequent access to these potentially biomedically-relevant materials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.