ArticleEnvironmental health : a global access science source2021
Severity of parkinsonism associated with environmental manganese exposure.
Article in Environmental health : a global access science source, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Prolonged duration induces divergent transcriptomic responses to manganese, distinct from concentration effects, in an SH-SY5Y neurotoxicity model.Neurotoxicology · 2026Article
- Utilizing T1-weighted MRI intensity indices to evaluate in-vivo neurotoxicity in a South African cohort with environmental manganese exposure.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Article
- Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy.Metabolites · 2025Article
- Manganese Neurotoxicity: A Comprehensive Review of Pathophysiology and Inherited and Acquired Disorders.Journal of xenobiotics · 2025Review
- The Effects of Air Pollution on Neurological Diseases: A Narrative Review on Causes and Mechanisms.Toxics · 2025Review
- Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy.medRxiv : the preprint server for health sciences · 2024Article
- Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024Review
- Air pollution, greenspace exposure and risk of Parkinson's disease: a prospective study of 441,462 participants.Journal of neurology · 2024Article
- Olfactory tract/bulb metal concentration in Manganese-exposed mineworkers.Neurotoxicology · 2024Article
- Trace Elements in Alzheimer's Disease and Dementia: The Current State of Knowledge.Journal of clinical medicine · 2024Review
- The association of manganese levels with red cell distribution width: A population-based study.PloS one · 2024Article
- Associations of ambient manganese exposure with brain gray matter thickness and white matter hyperintensities.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Dose-response relationship between multiple trace elements and risk of all-cause mortality: a prospective cohort study.Frontiers in nutrition · 2023Article
- Sex Differences in Dopaminergic Vulnerability to Environmental Toxicants - Implications for Parkinson's Disease.Current environmental health reports · 2022Review
- An Overview of the Relationship Between Occupational Manganese Exposure and Parkinsonism.Cureus · 2022Review
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Exposing the role of metals in neurological disorders: a focus on manganese.Trends in molecular medicine · 2022Review
- Environmental manganese exposure and cognitive control in a South African population.Neurotoxicology · 2022Article
- The association of bone and blood manganese with motor function in Chinese workers.Neurotoxicology · 2022Article
- Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies.Frontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundExposure to occupational manganese (Mn) is associated with neurotoxic brain injury, manifesting primarily as parkinsonism. The association between environmental Mn exposure and parkinsonism is unclear. To characterize the association between environmental Mn exposure and parkinsonism, we performed population-based sampling of residents older than 40 in Meyerton, South Africa (N = 621) in residential settlements adjacent to a large Mn smelter and in a comparable non-exposed settlement in Ethembalethu, South Africa (N = 95) in 2016-2020.
methodsA movement disorders specialist examined all participants using the Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3). Participants also completed an accelerometry-based kinematic test and a grooved pegboard test. We compared performance on the UPDRS3, grooved pegboard, and the accelerometry-based kinematic test between the settlements using linear regression, adjusting for covariates. We also measured airborne PM
resultsMean PM
conclusionsEnvironmental airborne Mn exposures at levels substantially lower than current occupational exposure thresholds in the United States may be associated with clinical parkinsonism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.