ArticleAdipocyte2021
Dysfunctional adiposity index as a marker of adipose tissue morpho-functional abnormalities and metabolic disorders in apparently healthy subjects.
Article in Adipocyte, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The adiponectin/leptin ratio as a biomarker of adiposopathy and visceral adipose tissue accumulation: sex-specific mechanisms.Adipocyte · 2026Article
- Predictive Performance of Seven Clinical Surrogates of Visceral Adipose Tissue for Cardiovascular Mortality: A Sub-Analysis of 102 385 Adults From the Mexico City Prospective Study.Diabetes, obesity & metabolism · 2026Article
- Early-life overconsumption of a high-carbohydrate diet induces metaflammation and kidney injury without impairment of function in adult Wistar rats.Journal of physiology and biochemistry · 2026Article
- A Comprehensive Evaluation of Adiposity Indices on 20-Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002-2022).Clinical obesity · 2026Article
- Predictive performance of seven clinical surrogates of visceral adipose tissue for cardiovascular mortality: A sub-analysis of 102,385 adults from the Mexico City Prospective Study.medRxiv : the preprint server for health sciences · 2026Article
- Predicting Metabolic Syndrome Using Supervised Machine Learning: A Multivariate Parameter Approach.International journal of molecular sciences · 2025Article
- Visceral and Dysfunctional Adiposity Indices as Predictors of Insulin Resistance and Metabolic Syndrome in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Extreme gradient boosting using conventional parameters accurately predicts insulin sensitivity in young and middle-aged Japanese persons.Frontiers in endocrinology · 2025Article
- The Potential of Metabolomics as a Tool for Identifying Biomarkers Associated with Obesity and Its Complications: A Scoping Review.International journal of molecular sciences · 2024Article
- Sex-Specific Cut-Offs of Seven Adiposity Indicators and Their Performance in Predicting Metabolic Syndrome in Arab Adults.Journal of clinical medicine · 2023Article
- Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity.Journal of personalized medicine · 2023Article
- The Role of Different Methods in Defining Cardiometabolic Risk and Metabolic Syndrome in Women with Polycystic Ovary Syndrome.Life (Basel, Switzerland) · 2023Article
- Exercise and Weight Management: The Role of Leptin-A Systematic Review and Update of Clinical Data from 2000-2022.Journal of clinical medicine · 2023Review
- Visceral adipose tissue is an independent predictor and mediator of the progression of coronary calcification: a prospective sub-analysis of the GEA study.Cardiovascular diabetology · 2023Article
- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- Cardiometabolic profile of 15057 elderly Spanish workers: association of sociodemographic variables and tobacco consumption.BMC geriatrics · 2022Article
- The CUN-BAE, Deurenberg Fat Mass, and visceral adiposity index as confident anthropometric indices for early detection of metabolic syndrome components in adults.Scientific reports · 2022Article
- Leptin-A Potential Bridge between Fat Metabolism and the Brain's Vulnerability to Neuropsychiatric Disorders: A Systematic Review.Journal of clinical medicine · 2021Review
- Adipose Tissue and Biological Factors. Possible Link between Lymphatic System Dysfunction and Obesity.Metabolites · 2021Review
- Determination of cardiovascular risk in Spanish veterinarians using different scaling methods.Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMTArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared to body mass index, waist circumference (WC), and adiposity measurements, adipose tissue (AT) morpho-functionality evaluations are better predictors of cardiometabolic abnormalities (CA). The present study establishes a dysfunctional adiposity index (DAI) as an early marker of CA based on adipocytes morpho-functional abnormalities. DAI was established in 340 subjects without cardiovascular risk factors selected from a cross-sectional study (n=1600). Then, DAI was calculated in 36 healthy subjects who underwent subcutaneous AT biopsy. The correlation of DAI with adipocyte morphology (size/number) and functionality (adiponectin/leptin ratio) was analyzed. The DAI cut-off point was identified and its independent association with CA was determined in 1418 subjects from the cross-sectional study. The constant parameters to calculate the DAI were [WC/[22.79+[2.68*BMI]]]*[triglycerides (TG, mmol/L)/1.37]*[1.19/high density lipoprotein-cholesterol (HDL-C, mmol/L)] for males, and [WC/[24.02+[2.37*BMI]]]*[TG(mmol/L)/1.32]*[1.43/HDL-C(mmol/L)] for females. DAI correlated with adipocytes mean area, adipocyte number and adiponectin/leptin ratio. DAI ≥1.065 was independently associated with diabetes, non-alcoholic fatty liver disease, subclinical atherosclerosis, and hypertension. The present study highlights that DAI is associated with early CA independently of adiposity and other risk factors. Since DAI is obtained using accessible parameters, it can be easily incorporated into clinical practice for early identification of AT abnormalities in apparently healthy subjects.
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