Evidence map›Paper›PMID 33722087›Full record

ArticleDiabetes & vascular disease research

Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb.

Laura Croteau, Clément Mercier, Étienne Fafard-Couture, Alexandre Nadeau, Stéphanie Robillard, Valérie Breton, Andréanne Guay, Farah Lizotte, Marc-Antoine Despatis, Pedro Geraldes

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Current Evidence on the Potential Role of EndothelialReviews in cardiovascular medicine · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laura CroteauResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Clément MercierResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Étienne Fafard-CoutureResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0001-9789-4650
Alexandre NadeauResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Stéphanie RobillardResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Valérie BretonResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Andréanne GuayResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Farah LizotteResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Marc-Antoine DespatisDepartment of Surgery of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Pedro GeraldesResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0002-2613-6710
Centre Hospitalier Universitaire de Sherbrooke · CAUniversité de Sherbrooke · CA

Funding

Canadian Institute of Health Research PTJ159627
6 · The paper itself

Abstract

aimsPeripheral artery disease is a complication of diabetes leading to critical hindlimb ischemia. Diabetes-induced inhibition of VEGF actions is associated with the activation of protein kinase Cδ (PKCδ). We aim to specifically investigate the role of PKCδ in endothelial cell (EC) function and VEGF signaling.

methodsNondiabetic and diabetic mice, with (

resultsIschemic muscle of diabetic

conclusionsOur data provide new highlights in mechanisms by which PKCδ activation in EC contributed to poor collateral vessel formation, thus, offering novel therapeutic targets to improve angiogenesis in the diabetic limb.

Indexed as

Neovascularization, PhysiologicAnimalsApoptosisCattleCells, CulturedCollateral CirculationDiabetes Mellitus, ExperimentalEndothelial CellsHindlimbIschemiaMiceMice, KnockoutMicrovascular DensityProtein Kinase C-deltaProtein Tyrosine Phosphatase, Non-Receptor Type 6Regional Blood FlowPrkcd protein, mouseProtein Kinase C-deltaProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseDiabetesperipheral arterial diseasePKCδSH2 domain-containing phosphatase 1vascular endothelial growth factor

Identifiers

PMID33722087
PMCPMC8481738
OpenAlexW3138712028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.