ArticlePlant physiology2021
Multi-omics approach reveals the contribution of KLU to leaf longevity and drought tolerance.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 41 citations in OpenAlex.
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- Comparative genomics reveals insights into the potential of Lysinibacillus irui as a plant growth promoter.Applied microbiology and biotechnology · 2024Article
- Multiomics Research: Principles and Challenges in Integrated Analysis.Biodesign research · 2024Review
- A CYP78As-small grain4-coat protein complex Ⅱ pathway promotes grain size in rice.The Plant cell · 2023Article
- Peeling back the layers of coral holobiont multi-omics data.iScience · 2023Article
- Comparative Functional Genome Analysis Reveals the Habitat Adaptation and Biocontrol Characteristics of Plant Growth-Promoting Bacteria in NCBI Databases.Microbiology spectrum · 2023Article
- Improving crop yield potential: Underlying biological processes and future prospects.Food and energy security · 2023Review
- Cell dehydration of intergeneric hybrid induces subgenome-related specific responses.Physiologia plantarum · 2023Article
- Past accomplishments and future challenges of the multi-omics characterization of leaf growth.Plant physiology · 2022Review
- Article
- An in situ sequencing approach maps PLASTOCHRON1 at the boundary between indeterminate and determinate cells.Plant physiology · 2022Article
- Modified expression of TaCYP78A5 enhances grain weight with yield potential by accumulating auxin in wheat (Triticum aestivum L.).Plant biotechnology journal · 2022Article
- Omics Path to Increasing Productivity in Less-Studied Crops Under Changing Climate-Lentil a Case Study.Frontiers in plant science · 2022Review
- KLU/CYP78A5, a Cytochrome P450 Monooxygenase IdentifiedFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KLU, encoded by a cytochrome P450 CYP78A family gene, generates an important-albeit unknown-mobile signal that is distinct from the classical phytohormones. Multiple lines of evidence suggest that KLU/KLU-dependent signaling functions in several vital developmental programs, including leaf initiation, leaf/floral organ growth, and megasporocyte cell fate. However, the interactions between KLU/KLU-dependent signaling and the other classical phytohormones, as well as how KLU influences plant physiological responses, remain poorly understood. Here, we applied in-depth, multi-omics analysis to monitor transcriptome and metabolome dynamics in klu-mutant and KLU-overexpressing Arabidopsis plants. By integrating transcriptome sequencing data and primary metabolite profiling alongside phytohormone measurements, our results showed that cytokinin signaling, with its well-established function in delaying leaf senescence, was activated in KLU-overexpressing plants. Consistently, KLU-overexpressing plants exhibited significantly delayed leaf senescence and increased leaf longevity, whereas the klu-mutant plants showed early leaf senescence. In addition, proline biosynthesis and catabolism were enhanced following KLU overexpression owing to increased expression of genes associated with proline metabolism. Furthermore, KLU-overexpressing plants showed enhanced drought-stress tolerance and reduced water loss. Collectively, our work illustrates a role for KLU in positively regulating leaf longevity and drought tolerance by synergistically activating cytokinin signaling and promoting proline metabolism. These data promote KLU as a potential ideal genetic target to improve plant fitness.
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