Evidence map›Paper›PMID 33721700›Full record

ReviewPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2021

Requirements and reliability of AI in the medical context.

Yoganand Balagurunathan, Ross Mitchell, Issam El Naqa

Abstract readReview
In one paragraph

Review in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yoganand BalagurunathanDepartment of Machine Learning, H. Lee. Moffitt Cancer Center, Tampa, FL, USA. Electronic address: yogab@moffitt.org.
Ross MitchellDepartment of Machine Learning, H. Lee. Moffitt Cancer Center, Tampa, FL, USA; Health Data Services, H. Lee. Moffitt Cancer Center, Tampa, FL, USA. Electronic address: ross.mitchell@moffitt.org.
Issam El NaqaDepartment of Machine Learning, H. Lee. Moffitt Cancer Center, Tampa, FL, USA. Electronic address: issam.elnaqa@moffitt.org.

Funding

Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapyR37CA222215 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EL NAQA, ISSAM M. · 2018 to 2024
$3.5M
MRI Imaging and Biomarkers for Early Detection of Aggressive Prostate CancerU01CA239141 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI POLLACK, ALAN, PUNNEN, SANOJ · 2019 to 2023
$3.0M
(PQC4) Habitats in Prostate CancerR01CA190105 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BALAGURUNATHAN, YOGANAND, GILLIES, ROBERT J. · 2014 to 2017
$2.8M
Optimal Decision Making in Radiotherapy Using Panomics AnalyticsR01CA233487 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EL NAQA, ISSAM M. · 2019 to 2023
$2.4M
Cerenkov Multi-Spectral Imaging (CMSI) for Adaptation and Real-Time Imaging in RadiotherapyR41CA243722 · NCI · ENDECTRA, LLC · PI EL NAQA, ISSAM M. · 2020 to 2020
$327k
CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM-NICHD CONTRACEPTIVE CLINICAL TRIALS NETWORK-FEMALE SITES-CORE FUNCTION ACTIVITIES75N94020D00018 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI CHEN, M.D., MPH, BEATRICE · 2020 to 2025
$40k
NCI NIH HHS R01 CA190105NCI NIH HHS R01 CA233487NCI NIH HHS R37 CA222215NCI NIH HHS R41 CA243722NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA200464NCI NIH HHS U01 CA239141NHLBI NIH HHS 75N92022D00018NHLBI NIH HHS 75N92023D00018NICHD NIH HHS 75N94020D00018ORFDO NIH HHS 75N99020D00018
6 · The paper itself

Abstract

The digital information age has been a catalyst in creating a renewed interest in Artificial Intelligence (AI) approaches, especially the subclass of computer algorithms that are popularly grouped into Machine Learning (ML). These methods have allowed one to go beyond limited human cognitive ability into understanding the complexity in the high dimensional data. Medical sciences have seen a steady use of these methods but have been slow in adoption to improve patient care. There are some significant impediments that have diluted this effort, which include availability of curated diverse data sets for model building, reliable human-level interpretation of these models, and reliable reproducibility of these methods for routine clinical use. Each of these aspects has several limiting conditions that need to be balanced out, considering the data/model building efforts, clinical implementation, integration cost to translational effort with minimal patient level harm, which may directly impact future clinical adoption. In this review paper, we will assess each aspect of the problem in the context of reliable use of the ML methods in oncology, as a representative study case, with the goal to safeguard utility and improve patient care in medicine in general.

Indexed as

Artificial IntelligenceMedicineAlgorithmsHumansMachine LearningReproducibility of ResultsArtificial intelligenceMachine learningMedical applicationsOncologyReliability

Identifiers

PMID33721700
PMCPMC8915137

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.