Evidence map›Paper›PMID 33721615›Full record

ReviewCurrent opinion in pharmacology2021

Circadian variations of vasoconstriction and blood pressure in physiology and diabetes.

Tianfei Hou, Zhenheng Guo, Ming C Gong

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Effect ofInternational journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tianfei HouDepartment of Physiology, University of Kentucky, College of Medicine, USA.
Zhenheng GuoPharmacology and Nutritional Sciences, University of Kentucky, College of Medicine, USA; Saha Cardiovascular Research Center, University of Kentucky, College of Medicine, USA.
Ming C GongDepartment of Physiology, University of Kentucky, College of Medicine, USA; Saha Cardiovascular Research Center, University of Kentucky, College of Medicine, USA. Electronic address: ming.gong@uky.edu.
University of Kentucky · US

Funding

Targeting timing of food intake as a novel strategy against disruption of blood pressure circadian rhythm in diabetesR01HL141103 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2019 to 2022
$2.5M
Regulation of Blood Pressure Circadian Rhythm by Vascular Smooth Muscle BMAL1R01HL106843 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2012 to 2015
$2.0M
Vascular Smooth Muscle Hyper-contractility/HypertensionR01HL082791 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C · 2006 to 2010
$1.6M
NHLBI NIH HHS R01 HL082791NHLBI NIH HHS R01 HL106843NHLBI NIH HHS R01 HL141103
6 · The paper itself

Abstract

The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

Indexed as

Diabetes MellitusVasoconstrictionAnimalsBlood PressureCircadian RhythmMiceBlood pressureBmal1CircadianClockDiabetesSmooth muscleVasoconstriction

Identifiers

PMID33721615
PMCPMC8164980
OpenAlexW3136681299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.