Evidence map›Paper›PMID 33721571›Full record

ArticleBiomaterials2021

Transpupillary collagen photocrosslinking for targeted modulation of ocular biomechanics.

B G Gerberich, B G Hannon, A Hejri, E J Winger, E Schrader Echeverri, L M Nichols, H G Gersch, N A MacLeod, S Gupta, A T Read and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Biomechanical Modification of the Sclera: An Ex Vivo Study on Porcine Eyes.Investigative ophthalmology & visual science · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

B G GerberichWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
B G HannonGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
A HejriSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
E J WingerSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
E Schrader EcheverriWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
L M NicholsSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
H G GerschWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
N A MacLeodWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
S GuptaDaniel Guggenheim School of Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
A T ReadWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
M D RitchWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
S SridharWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
M G ToothmanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
G S GershonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
S A SchwanerGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
G Sánchez-RodríguezWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
V GoyalSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
A M ToporekWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
A J FeolaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Decatur, GA, USA.
H E GrossniklausWinship Cancer Institute of Emory University, Atlanta, GA, USA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
M T PardueWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Decatur, GA, USA.
C R EthierWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: ross.ethier@bme.gatech.edu.
M R PrausnitzWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: prausnitz@gatech.edu.
Georgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · USEmory University · US

Funding

Targeting Scleral Stiffness as a Novel Therapeutic Approach in GlaucomaR01EY025286 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ETHIER, C ROSS · 2015 to 2019
$2.5M
The Effect of Estrogen Deficiencies on Vision Loss in GlaucomaIK2RX002342 · VA · VETERANS HEALTH ADMINISTRATION · PI FEOLA, ANDREW J · 2018 to 2023
–
RR&D Research Career Scientist Award ApplicationIK6RX003134 · VA · VETERANS HEALTH ADMINISTRATION · PI PARDUE, MACHELLE T. · 2019 to 2025
–
NEI NIH HHS R01 EY025286RRD VA IK2 RX002342RRD VA IK6 RX003134
6 · The paper itself

Abstract

The central vision-threatening event in glaucoma is dysfunction and loss of retinal ganglion cells (RGCs), thought to be promoted by local tissue deformations. Here, we sought to reduce tissue deformation near the optic nerve head by selectively stiffening the peripapillary sclera, i.e. the scleral region immediately adjacent to the optic nerve head. Previous scleral stiffening studies to treat glaucoma or myopia have used either pan-scleral stiffening (not regionally selective) or regionally selective stiffening with limited access to the posterior globe. We present a method for selectively stiffening the peripapillary sclera using a transpupillary annular light beam to activate methylene blue administered by retrobulbar injection. Unlike prior approaches to photocrosslinking in the eye, this approach avoids the damaging effects of ultraviolet light by employing red light. This targeted photocrosslinking approach successfully stiffened the peripapillary sclera at 6 weeks post-treatment, as measured by whole globe inflation testing. Specifically, strain was reduced by 47% when comparing treated vs. untreated sclera within the same eye (n = 7, p=0.0064) and by 54% when comparing the peripapillary sclera of treated vs. untreated eyes (n = 7, p<0.0001). Post-treatment characterization of RGCs (optic nerve axon counts/density, and grading), retinal function (electroretinography), and retinal histology revealed that photocrosslinking was associated with some ocular toxicity. We conclude that a transpupillary photocrosslinking approach enables selective scleral stiffening targeted to the peripapillary region that may be useful in future treatments of glaucoma.

Indexed as

GlaucomaOptic DiskBiomechanical PhenomenaCollagenHumansIntraocular PressureScleraCollagenCollagen photocrosslinkingGlaucomaMethylene blueMyopiaOcular biomechanicsScleral stiffening

Identifiers

PMID33721571
PMCPMC8044034
OpenAlexW3131272466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.