Evidence map›Paper›PMID 33721552›Full record

ArticleeLife2021

Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task.

Hongdian Yang, Bilal A Bari, Jeremiah Y Cohen, Daniel H O'Connor

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Effects of Phasic Activation of Locus Ceruleus on Cortical Neural Activity and Auditory Discrimination Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hongdian YangDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.ORCID 0000-0002-5203-9519
Bilal A BariDepartment of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United States.
Jeremiah Y CohenDepartment of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United States.ORCID 0000-0002-4768-7124
Daniel H O'ConnorDepartment of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United States.ORCID 0000-0002-9193-6714

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Top-Down Mechanisms and Modulation of Flexible Tactile DiscriminationR01NS112200 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Hongdian Yang, Edward W Zagha · 2019 to 2026
$2.8M
Circuit and cellular dynamics in mouse cortex during tactile detectionR01NS089652 · NINDS · JOHNS HOPKINS UNIVERSITY · PI O'CONNOR, DANIEL HANS · 2014 to 2019
$2.1M
Locus Coeruleus-Norepinephrine Modulation of Sensory Response and Tactile PerceptionR01NS107355 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI YANG, HONGDIAN · 2019 to 2023
$1.7M
The role of norepinephrine in enabling behavioral change during uncertaintyF30MH110084 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BARI, BILAL ABDUL · 2016 to 2018
$147k
Klingenstein-Simons Fellowship Awards in NeuroscienceNIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM136577NIMH NIH HHS F30 MH110084NIMH NIH HHS F30MH110084NINDS NIH HHS 1R01NS104834-01NINDS NIH HHS 1R01NS107355NINDS NIH HHS 1R01NS112200NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS089652NINDS NIH HHS R01NS089652NINDS NIH HHS R01 NS104834NINDS NIH HHS R01 NS107355NINDS NIH HHS R01 NS112200
6 · The paper itself

Abstract

We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.

Indexed as

AnimalsDilatationElectric StimulationFemaleLocus CoeruleusMaleMicePupilRewardSomatosensory CortexTouch Perceptionlocus coeruleusmouseneurosciencenorepinephrinepupilS1somatosensory cortextactile

Identifiers

PMID33721552
PMCPMC7963470

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.