Evidence map›Paper›PMID 33721518›Full record

GuidelineAnnals of internal medicine2021

What Is the Antibody Response and Role in Conferring Natural Immunity After SARS-CoV-2 Infection? Rapid, Living Practice Points From the American College of Physicians (Version 1).

Amir Qaseem, Jennifer Yost, Itziar Etxeandia-Ikobaltzeta, Mary Ann Forciea, George M Abraham, Matthew C Miller, Adam J Obley, Linda L Humphrey, Scientific Medical Policy Committee of the American College of Physicians, Robert M Centor and 5 more

Open access · greenAbstract readPractice Guideline
In one paragraph

Guideline in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Amir QaseemAmerican College of Physicians, Philadelphia, Pennsylvania (A.Q., I.E.).ORCID 0000-0001-6866-7985
Jennifer YostAmerican College of Physicians, Philadelphia, and Villanova University, Villanova, Pennsylvania (J.Y.).ORCID 0000-0002-3170-1956
Itziar Etxeandia-IkobaltzetaAmerican College of Physicians, Philadelphia, Pennsylvania (A.Q., I.E.).ORCID 0000-0001-6606-649X
Mary Ann ForcieaPenn Medicine, Philadelphia, Pennsylvania (M.A.F., M.C.M.).ORCID 0000-0002-1999-1145
George M AbrahamUniversity of Massachusetts Medical School and Saint Vincent Hospital, Worcester, Massachusetts (G.M.A.).ORCID 0000-0003-4296-8362
Matthew C MillerPenn Medicine, Philadelphia, Pennsylvania (M.A.F., M.C.M.).ORCID 0000-0001-7267-4897
Adam J ObleyPortland Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon (A.J.O., L.L.H.).
Linda L HumphreyPortland Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon (A.J.O., L.L.H.).
Scientific Medical Policy Committee of the American College of Physicians
Robert M Centor
Elie A Akl
Rebecca Andrews
Thomas A Bledsoe
Ray Haeme
Devan L Kansagara
American College of Physicians · USOregon Health & Science University · USPenn Center for AIDS Research · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

descriptionThe widespread availability of SARS-CoV-2 antibody tests raises important questions for clinicians, patients, and public health professionals related to the appropriate use and interpretation of these tests. The Scientific Medical Policy Committee (SMPC) of the American College of Physicians developed these rapid, living practice points to summarize the current and best available evidence on the antibody response to SARS-CoV-2 infection, antibody durability after initial infection with SARS-CoV-2, and antibody protection against reinfection with SARS-CoV-2.

methodsThe SMPC developed these rapid, living practice points based on a rapid and living systematic evidence review done by the Portland VA Research Foundation and funded by the Agency for Healthcare Research and Quality. Ongoing literature surveillance is planned through December 2021. When new studies are identified and a full update of the evidence review is published, the SMPC will assess the new evidence and any effect on the practice points. PRACTICE POINT 1: PRACTICE POINT 2: PRACTICE POINT 3:

Indexed as

Antibody FormationAntibodies, ViralCOVID-19COVID-19 TestingHumansImmunity, InnateSARS-CoV-2Antibodies, Viral

Identifiers

PMID33721518
PMCPMC8017476
OpenAlexW3136454651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.