SynthesisClinical endocrinology2021
Presentation and outcomes of adrenal ganglioneuromas: A cohort study and a systematic review of literature.
Synthesis in Clinical endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adrenal schwannomas and adrenal ganglioneuromas: our experience and CT characteristic-focused systematic review.Endocrine · 2026Pooled it
- Clinical characteristics and management of adrenal ganglioneuroma: a single center retrospective study.Endocrine · 2026Article
- The clinical spectrum of adrenal ganglioneuromas extends from severe hypertension to an asymptomatic incidentaloma; two cases and mini review of literature.Hormones (Athens, Greece) · 2025Review
- A potentially dangerous case of mistaken identity: giant asymptomatic composite phaeochromocytoma.Endocrinology, diabetes & metabolism case reports · 2025Article
- Case Report: Adrenal schwannoma associated with ganglioneuroma.Frontiers in surgery · 2024Article
- Giant ganglioneuroma of the mediastinum: a case report.Frontiers in oncology · 2024Article
- Combined exploratory laparotomy, transpsoas, and thoracic approach to resection of a giant spinal ganglioneuroma: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Urology case reports: Rapidly growing adrenal ganglioneuroma in a young man.Urology case reports · 2022Article
- Review
- Approach to the Patient With Adrenal Incidentaloma.The Journal of clinical endocrinology and metabolism · 2021Review
- Adrenal ganglioneuroma resected for suspicious malignancy: multicenter review of 25 cases and review of the literature.Annals of surgical treatment and research · 2021Article
- Two Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveTo describe the presentation and outcomes of patients with adrenal ganglioneuromas (AGNs).
designSingle-centre retrospective cohort study (1 January 1995 to 31 December 2019) and systematic review of literature (1 January 1980 to 19 November 2019). PATIENTS: Diagnosed with histologically confirmed AGN. MEASUREMENTS: Baseline clinical, imaging and biochemical characteristics, recurrence rates and mortality. Subgroup analysis was performed on tumours with histologic elements of ganglioneuroma and pheochromocytoma (ie composite tumours).
resultsThe cohort study included 45 patients with AGN, 20 (44%) of which had composite tumours. Compared to pure AGN, patients with composite tumour were older (median age, 62.5 vs. 35 years, p < .001), had smaller tumours (median size, 3.9 vs. 5.7 cm, p = .016) and were discovered incidentally less frequently (65% vs. 84%, p = .009). No recurrences or ganglioneuroma-specific mortality occurred during follow-up (range, 0-266 months). The systematic review included 14 additional studies and 421 patients. The mean age of diagnosis was 39 years, and 47% were women. AGNs were discovered incidentally in 72% of patients, were predominantly unilateral (99%) and had a mean diameter of 5.8 cm and an unenhanced computed tomography (CT) attenuation of -118 to 49 Hounsfield units (HU). On imaging, 69% of AGNs were homogenous, 41% demonstrated calcifications, and 40% were lobulated.
conclusionsAGNs are rare benign tumours that present with variable imaging features including large size, unenhanced CT attenuation >20 HU, calcifications and lobulated shape. Imaging characteristics can assist in establishing a diagnosis and avoiding an unnecessary adrenalectomy. The association of pheochromocytomas with AGNs is frequent. Diagnosis should include biochemical testing.
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