ArticleClinical endocrinology2021
The incidence of brain lesions in central precocious puberty: The main cause for Chinese boys was idiopathic.
Article in Clinical endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 15 citations in OpenAlex.
- Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.Frontiers in endocrinology · 2026Review
- Prevalence and effects on outcomes of intracranial tumors and structural alterations in children with central precocious puberty and early and fast puberty.Frontiers in endocrinology · 2026Article
- Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion.Endocrine connections · 2025Article
- Brain structural changes in girls with idiopathic central precocious puberty: a voxel-based morphometry and surface-based morphometry analysis.Frontiers in endocrinology · 2025Article
- Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort.The Journal of clinical endocrinology and metabolism · 2024Article
- MRI evaluation of cranial pathologies in rapidly progressive early puberty cases aged 8-9.Frontiers in endocrinology · 2023Article
- Commentary on "Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam".Annals of pediatric endocrinology & metabolism · 2022Article
- The incidence of brain lesions in central precocious puberty: The main cause for Chinese boys was idiopathic.Clinical endocrinology · 2021Article
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8 authors at 1 institution in 1 country.
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Abstract
objectiveMany studies show that brain lesions are the main cause of central precocious puberty (CPP) in males. However, the association rate has not been reported in China. This study aimed to assess the frequency of both abnormal and likely pathologic brain lesions by magnetic resonance imaging (MRI) in Chinese boys with CPP.
designThis is a retrospective cross-sectional single-centre study. PATIENTS: 396 CPP boys were recruited from 2011 to 2019 in Children's Hospital, Zhejiang University School of Medicine, and 129 were eligible for our study. MEASUREMENTS: Diagnosis age, bone age, weight (kg), height (cm), puberty stage, MRI results and levels of sexual hormone were analysed.
resultsThe number of CPP boys is increasing from 2011 to 2019 in China. Brain MRI findings were normal in 83.7% of CPP boys. Only 21 (16.3%) CPP boys were found with abnormal MRI findings including hamartoma, pineal cyst and other minor changes.
conclusionIn China, there is an increasing trend of male CPP over the last decade and the main cause is idiopathic, rather than pathogenic brain lesions. Further investigations about the aetiology for CPP with pathological brain lesions are needed.
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