Evidence map›Paper›PMID 33721199›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2021

Intranasal administration of 40 and 80 units of insulin does not cause hypoglycemia during cardiac surgery: a randomized controlled trial.

Patricia Roque, Yosuke Nakadate, Hiroaki Sato, Tamaki Sato, Linda Wykes, Akiko Kawakami, Hiroshi Yokomichi, Takashi Matsukawa, Thomas Schricker

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02729064 (Effect of Intranasal Insulin Administration on Glycaemia and Insulin Concentrations in Plasma and Cerebrospinal Fluid During Surgery), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02729064 phase1unknown statusnot on this map

Effect of Intranasal Insulin Administration on Glycaemia and Insulin Concentrations in Plasma and Cerebrospinal Fluid During Surgery

TypeinterventionalSponsorHiroaki Sato, MD., PhD.Ran2016 to 2021Enrolled141ConditionsIschemic Heart Disease, Aortic AneurysmArmsHumulin R, Normal Saline
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Patricia Roque *School of Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Montreal, QC, Canada.
Yosuke Nakadate *Department of Anesthesiology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan. ynakadate@yamanashi.ac.jp.ORCID http://orcid.org/0000-0002-5095-2072
Hiroaki SatoDepartment of Anesthesia, McGill University Health Centre Glen Site, Royal Victoria Hospital, Montreal, QC, Canada.
Tamaki SatoDepartment of Anesthesia, McGill University Health Centre Glen Site, Royal Victoria Hospital, Montreal, QC, Canada.
Linda WykesSchool of Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Montreal, QC, Canada.
Akiko KawakamiDepartment of Anesthesia, McGill University Health Centre Glen Site, Royal Victoria Hospital, Montreal, QC, Canada.
Hiroshi YokomichiDepartment of Health science, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Takashi MatsukawaDepartment of Health science, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Thomas SchrickerDepartment of Anesthesia, McGill University Health Centre Glen Site, Royal Victoria Hospital, Montreal, QC, Canada.
Royal Victoria Regional Health Centre · CAUniversity of Yamanashi Hospital · JPMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntranasal insulin administration may improve cognitive function in patients with dementia and may prevent cognitive problems after surgery. Although the metabolic effects of intranasal insulin in non-surgical patients have been studied, its influence on glucose concentration during surgery is unknown.

methodsWe conducted a randomized, double-blind, placebo-contolled trial in patients scheduled for elective cardiac surgery. Patients with type 2 diabetes mellitus (T2DM) and non-T2DM patients were randomly allocated to one of three groups (normal saline, 40 international units [IU] of intranasal insulin, and 80 IU intranasal insulin). Insulin was given after the induction of general anesthesia. Glucose and plasma insulin concentrations were measured in ten-minute intervals during the first hour and every 30 min thereafter. The primary outcome was the change in glucose concentration 30 min after intranasal insulin administration.

resultsA total of 115 patients were studied, 43 of whom had T2DM. In non-T2DM patients, 40 IU intranasal insulin did not affect glucose concentration, while 80 IU intranasal insulin led to a statistically significant but not clinically important decrease in blood glucose levels (mean difference, 0.4 mMol·L

conclusionsIn patients with and without T2DM undergoing elective cardiac surgery, intranasal insulin administration at doses as high as 80 IU did not cause clinically important hypoglycemia.

trial registrationwww.ClinicalTrials.gov (NCT02729064); registered 5 April 2016.

Indexed as

Cardiac Surgical ProceduresDiabetes Mellitus, Type 2HypoglycemiaAdministration, IntranasalBlood GlucoseDouble-Blind MethodHumansHypoglycemic AgentsInsulinBlood GlucoseHypoglycemic AgentsInsulincardiac surgerydeliriumglycemiaintranasal insulin

Identifiers

PMID33721199
OpenAlexW3138277658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.