Evidence map›Paper›PMID 33721159›Full record

ArticleDigestive diseases and sciences2022

Early-Onset Colorectal Cancer Is Associated with a Lower Risk of Metachronous Advanced Neoplasia than Traditional-Onset Colorectal Cancer.

Frank W Chen, Liu Yang, Vivy T Cusumano, Michelle C Chong, Jonathan K Lin, Diana Partida, Folasade P May

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Guideline
  3. Review
  4. Article
  5. Early-onset Colorectal Cancer Patients Do Not Require Shorter Intervals for Post-surgical Surveillance Colonoscopy.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Frank W ChenDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Liu YangDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Vivy T CusumanoDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Michelle C ChongDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Jonathan K LinDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Diana PartidaDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Folasade P MayDepartment of Medicine, UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA. fmay@mednet.ucla.edu.ORCID 0000-0001-6706-8171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) incidence in the USA has increased in adults under age 50. Current CRC surveillance guidelines do not consider age at diagnosis, and there are limited data available on outcomes from surveillance colonoscopies in early-onset CRC (EO-CRC) to guide recommendations on surveillance intervals.

aimsTo compare surveillance outcomes between EO-CRC and traditional-onset colorectal cancer (TO-CRC).

methodsIn a retrospective cohort study in a large tertiary care academic medical center, we collected data on patients with a diagnosis of CRC between 2000 and 2014 who received surgery with curative intent. We used log-rank test and inverse probability of treatment weighted Cox regression analysis to compare the development of metachronous advanced neoplasia (MAN) in patients with EO-CRC (diagnosed ages 18-49) and TO-CRC (diagnosed ages 50-75).

resultsPatients with EO-CRC (n = 107) were more likely to present with advanced-stage disease (62% versus 35%, p < 0.0001), rectal tumors (45% versus 27%, p < 0.01), and a family history of CRC (30% versus 16%, p = 0.02) compared to those with TO-CRC (n = 139). Patients with EO-CRC had lower risk of MAN (adjusted HR 0.44, 95% CI 0.22-0.88) than TO-CRC patients. The 5-year event rate for MAN was lower for patients with EO-CRC compared to patients with TO-CRC (5.8% vs. 16.1%, p = 0.07). The presence of synchronous neoplasia or history of diabetes was also predictive of MAN.

conclusionsEO-CRC was independently associated with a lower risk of developing MAN compared to TO-CRC. Shorter surveillance intervals may not be warranted in EO-CRC; however, large prospective studies are needed.

Indexed as

Colorectal NeoplasmsNeoplasms, Second PrimaryAdolescentAdultAgedColonoscopyHumansMiddle AgedRetrospective StudiesRisk FactorsYoung AdultEarly-onset colorectal cancerMetachronous advanced neoplasiaSurveillance colonoscopy

Identifiers

PMID33721159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.