ArticleAnnals of intensive care2021
Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Determinants of abnormal liver-related biomarkers in adult COVID-19 patients.Frontiers in cellular and infection microbiology · 2025Article
- Article
- Remimazolam tosylate's long-term sedative properties in ICU patients on mechanical ventilation: effectiveness and safety.European journal of medical research · 2023Observational
- Association between acute liver injury & severity and mortality of COVID-19 patients: A systematic review and meta-analysis.Heliyon · 2023Article
- Identification of Clinical Response Predictors of Tocilizumab Treatment in Patients with Severe COVID-19 Based on Single-Center Experience.Journal of clinical medicine · 2023Article
- Acute liver injury in COVID-19 patients hospitalized in the intensive care unit: Narrative review.World journal of gastroenterology · 2022Review
- Liver injury in COVID-19: A minireview.World journal of gastroenterology · 2022Review
- Clinical predictors of recovery of COVID-19 associated-abnormal liver function test 2 months after hospital discharge.Scientific reports · 2022Article
- Use of CytoSorb© Hemoadsorption in Patients on Veno-Venous ECMO Support for Severe Acute Respiratory Distress Syndrome: A Systematic Review.Journal of clinical medicine · 2022Review
- Using machine learning in prediction of ICU admission, mortality, and length of stay in the early stage of admission of COVID-19 patients.Annals of operations research · 2022Article
- Prevalence, Outcomes, and Management of Ventricular Arrhythmias in COVID-19 Patients.Cardiac electrophysiology clinics · 2022Review
- An Adverse Outcomes Approach to Study the Effects of SARS-CoV-2 in 3D Organoid Models.Journal of molecular biology · 2022Review
- Influence of Co-morbidities During SARS-CoV-2 Infection in an Indian Population.Frontiers in medicine · 2022Article
- SARS-CoV-2 infection in people with pre-existing liver disease: Further research is warranted.World journal of gastroenterology · 2021Article
- Kinetics of Bilirubin and Ammonia Elimination during Hemadsorption Therapy in Secondary Sclerosing Cholangitis Following ECMO Therapy and Severe COVID-19.Biomedicines · 2021Article
- Liver function as a predictor of mortality in COVID-19: A retrospective study.Annals of hepatology · 2021Article
- Characteristics and Risk Factors for Intensive Care Unit Cardiac Arrest in Critically Ill Patients with COVID-19-A Retrospective Study.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunction (SLD) in critically ill with COVID-19 are lacking. We evaluated the occurrence, clinical characteristics and outcome of SLD in critically ill patients with COVID-19.
methodsClinical course and laboratory was analyzed from all patients with confirmed COVID-19 admitted to ICU of the university hospital. SLD was defined as: bilirubin ≥ 2 mg/dl or elevation of aminotransferase levels (> 20-fold ULN).
results72 critically ill patients were identified, 22 (31%) patients developed SLD. Presenting characteristics including age, gender, comorbidities as well as clinical presentation regarding COVID-19 overlapped substantially in both groups. Patients with SLD had more severe respiratory failure (paO
conclusionOne-third of critically ill patients with COVID-19 suffer from SLD, which is associated with high mortality. Occurrence of viremia and severity of illness seem to contribute to occurrence of SLD and underline the multifactorial cause.
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