Evidence map›Paper›PMID 33721105›Full record

ReviewCurrent oncology reports2021

Strategies Towards Improving Clinical Outcomes of Peptide Receptor Radionuclide Therapy.

N S Minczeles, J Hofland, W W de Herder, T Brabander

Open access · hybridAbstract readReview
In one paragraph

Review in Current oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Peptide Receptor Radionuclide Therapy.The Journal of clinical endocrinology and metabolism · 2022
    Article
  7. Clinical Utility ofCancers · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

N S MinczelesDepartment of Internal Medicine, Section of Endocrinology, Erasmus MC and Erasmus MC Cancer Center, Rotterdam, The Netherlands.
J HoflandDepartment of Internal Medicine, Section of Endocrinology, Erasmus MC and Erasmus MC Cancer Center, Rotterdam, The Netherlands.
W W de HerderDepartment of Internal Medicine, Section of Endocrinology, Erasmus MC and Erasmus MC Cancer Center, Rotterdam, The Netherlands.
T BrabanderDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. t.brabander@erasmusmc.nl.
Erasmus MC · NLErasmus MC Cancer Institute · NLRotterdam University of Applied Sciences · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPeptide receptor radionuclide therapy (PRRT) with [ RECENT

findingsPromising results were published regarding PRRT in other NENs, including lung NENs or high-grade NENs, and applying PRRT as neoadjuvant or salvage therapy. Furthermore, a diversity of strategic approaches, including dosimetry, somatostatin receptor antagonists, somatostatin receptor upregulation, radiosensitization, different radionuclides, albumin binding, alternative renal protection, and liver-directed therapy in combination with PRRT, have the potential to improve the outcome of PRRT. Also, novel biomarkers are presented that could predict response to PRRT. Multiple preclinical and early clinical studies have shown encouraging potential to advance the clinical outcome of PRRT in NEN patients. However, at this moment, most of these strategies have not yet reached the clinical setting of randomized phase III trials.

Indexed as

HumansIntestinal NeoplasmsNeoadjuvant TherapyNeuroendocrine TumorsOctreotideOrganometallic CompoundsPancreatic NeoplasmsRadioisotopesReceptors, PeptideReceptors, SomatostatinSalvage TherapySomatostatinStomach Neoplasmslutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadioisotopesReceptors, PeptideReceptors, SomatostatinSomatostatinNeuroendocrine tumourPeptide receptor radionuclide therapy

Identifiers

PMID33721105
PMCPMC7960621
OpenAlexW3138994660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.