Evidence map›Paper›PMID 33720887›Full record

Observational studyJournal of Alzheimer's disease : JAD2021

Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project.

Eleni Poptsi, Magda Tsolaki, Sverre Bergh, Bruno Mario Cesana, Alfonso Ciccone, Andrea Fabbo, Giovanni B Frisoni, Lutz Frölich, Sara Lavolpe, Anna Giulia Guazzarini and 3 more

Erratum issuedOpen access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Cost-effectiveness of the special care unit for persons with dementia.The journal of prevention of Alzheimer's disease · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 6 countries.

Eleni PoptsiLaboratory of Psychology, Section of Cognitive and Experimental Psychology, Faculty of Philosophy, School of Psychology, Aristotle University of Thessaloniki (AUTh), Macedonia, Hellas.
Magda TsolakiGreek Association of Alzheimer's Disease and Related Disorders (GAADRD), Thessaloniki, Makedonia, Hellas.
Sverre BerghResearch centre for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.
Bruno Mario CesanaDepartment of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics"Giulio A. Maccacaro" Faculty of Medicine and Surgery, University of Milan, Milan, Italy.
Alfonso CicconeDepartment of Neurology with Neurosurgical Activity "Carlo Poma" Hospital, ASST di Mantova, Mantua, Italy.
Andrea FabboDirettore UOC di Geriatria-Disturbi Cognitivi e Demenze, Dipartimento Cure Primarie AUSL, Modena, Italy.
Giovanni B FrisoniMemory Clinic, University Hospitals and University of Geneva, Geneva, Switzerland.
Lutz FrölichDepartment of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sara LavolpeDepartment of Neurology and CDCD Centre Humanitas Gavazzeni, Bergamo, Italy.
Anna Giulia GuazzariniInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Italy.
Jacques HugonCenter of Cognitive Neurology Université de Paris, Paris, France.
Sara FascendiniFERB Alzheimer Centre, Gazzaniga, Italy.
Carlo Alberto DefantiFERB Alzheimer Centre, Gazzaniga, Italy.
Aristotle University of Thessaloniki · GRFondazione Europea Ricerca Biomedica · ITAzienda Ospedaliera Carlo Poma · ITAzienda Unita' Sanitaria Locale Di Modena · ITHeidelberg University · DEHumanitas Gavazzeni · ITInnlandet Hospital Trust · NOUniversité Paris Cité · FRUniversity of Geneva · CHUniversity of Milan · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBehavioral and psychological symptoms of dementia (BPSD) are quite challenging problems during the dementia course. Special Care Units for people with dementia (PwD) and BPSD (SCU-B) are residential medical structures, where BPSD patients are temporarily admitted, in case of unmanageable behavioral disturbances at home.

objectiveRECage (REspectful Caring for AGitated Elderly) aspires to assess the short and long-term effectiveness of SCU-Bs toward alleviating BPSD and improving the quality of life (QoL) of PwD and their caregivers.

methodsRECage is a three-year, prospective study enrolling 500 PwD. Particularly, 250 community-dwelling PwDs presenting with severe BPSD will be recruited by five clinical centers across Europe, endowed with a SCU-B, for a short period of time; a second similar group of 250 PwD will be followed by six other no-SCU-B centers solely via outpatient visits. RECage's endpoints include short and long-term SCU-B clinical efficacy, QoL of patients and caregivers, cost-effectiveness of the SCU-B, psychotropic drug consumption, caregivers' attitude toward dementia, and time to nursing home placement.

resultsPwD admitted in SCU-Bs are expected to have diminished rates of BPSD and better QoL and their caregivers are also expected to have better QoL and improved attitude towards dementia, compared to those followed in no-SCU-Bs. Also, the cost of care and the psychotropic drug consumption are expected to be lower. Finally, PwD followed in no-SCU-Bs are expected to have earlier admission to nursing homes.

conclusionThe cohort study results will refine the SCU-B model, issuing recommendations for implementation of SCU-Bs in the countries where they are scarce or non-existent.

Indexed as

Adaptation, PsychologicalAgedAged, 80 and overCaregiversDementiaEuropeFemaleHumansIndependent LivingMaleProspective StudiesPsychotropic DrugsQuality of LifeResearch DesignSurveys and QuestionnairesPsychotropic DrugsBehavioral disturbancesdementiaspecial care units

Identifiers

PMID33720887
PMCPMC8203243
OpenAlexW3137338940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.